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Immune system disorders: from molecular mechanisms to clinical implications
In recent years, the increase in knowledge about the functioning of the immune system has revealed not only its importance in the defense against external agents such as pathogens or toxins, but also in the control of tumor cells and the importance of the processes of inflammation or immunological tolerance. On the one hand, all this knowledge has allowed a better understanding of the putative pathogenic consequences of immune system dysfunction, which includes inflammatory, autoimmune and immunosuppressive diseases, among others. On the other hand, current knowledge about immunoregulation has paved the way to better prevent or control transplantation rejection. However, such mechanisms unde...
Cancer Research
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T Cell Regulation by the Environment
Naïve T cells get activated upon encounter with their cognate antigen and differentiate into a specific subset of effector cells. These T cells are themselves plastic and are able to re-differentiate into another subset, changing both phenotype and function. Differentiation into a specific subset depends on the nature of the antigen and of the environmental milieu. Notably, certain nutrients, such as vitamins A and D, sodium chloride, have been shown to modulate T cell responses and influence T cell differentiation. Parasite infection can also skew Th differentiation. Similarly, the gut microbiota regulates the development of immune responses. Lastly, the key role of metabolism on T cells has also been demonstrated. This series of articles highlights some of the multiple links existing between environmental factors and T cell responses.
Nanopharmaceuticals in Regenerative Medicine
The book Nanopharmaceuticals in regenerative medicine is a collective and comprehensive volume of the latest innovations in nanoscience technology for practical use in clinical, biomedicine and diagnostic arena. The term nanotechnology pops up in every segment of modern-day life. The primary aim of this book is to deliver the precise information to students, educators, technologists and researchers. A conglomerate of scientists from various research fields contributed to the chapters, giving detailed descriptions on the most recent developments of nanotechnology in the area of disease management. This book will also be useful for industrial research and development partners, start-up entrepreneurs, government policy makers and other professionals who are interested in nanomedicines. Chapter 8 of this book is freely available as a downloadable Open Access PDF at Nanopharmaceuticals in Regenerative Medicine | Harishkumar Madhyastha, (taylorfrancis.com) under a Creative Commons CC-BY 4.0 license.
Immunometabolism
This detailed book showcases the tremendous effort and progress made in developing techniques and protocols for the study of immunometabolism, and in utilizing recent technological advances for probing and manipulating adipose and immune cells, and subsequently, their functions and immunometabolic consequences. Written by experts in the field, many chapters use macrophages as a model immune cell type, due to their prominence in the innate immune system and the exhaustive study of their traits. Protocols using adipocytes, dendritic cells, and T cells as model cell lines, as well as measurement of glucose metabolism at the systemic level, have also been included. Written for the highly successful Methods in Molecular Biology book series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Immunometabolism: Methods and Protocols serves as a vital guide for researchers working at the important interface of immunology and metabolism.
Cyberpunk 2077: Big City Dreams
Winner, 2023 Hugo Award—Best Graphic Story or Comic! Two scavengers veer paths in their pursuit of happiness through the streets of Night City. Tasha and Mirek make a living for themselves stealing cyberware and indulging in parties and braindances. Tasha is rowdy and wild--she seeks to up her street cred to become the most famous gangster in the city. Mirek, on the other hand, is a calm introvert--he longs for something more--meaning, belonging, warmth. He soon finds hope in an unexpected braindance. As he and Tasha chase their dreams, their paths begin to deviate. Where will they find the happiness they've been searching for? Does it even exist to be found? One thing they can both agree on, in a place like Night City--you run, you fight, you change, or you die. Written by Bartosz Sztybor (CD PROJEKT RED writer and narrative manager, Witcher: Fading Memories)) with art by Filipe Andrade (Old Man Logan, Rocket Raccoon & Groot) and Alessio Fioriniello (Paris Fashion Slam) comes a tale about the demanding life of Night City--where lives are lost, dreams are shattered, and hope is found in what remains.
Cyberpunk 2077: Big City Dreams
Winner, 2023 Hugo Award—Best Graphic Story or Comic! Two scavengers veer paths in their pursuit of happiness through the streets of Night City. Tasha and Mirek make a living for themselves stealing cyberware and indulging in parties and braindances. Tasha is rowdy and wild--she seeks to up her street cred to become the most famous gangster in the city. Mirek, on the other hand, is a calm introvert--he longs for something more--meaning, belonging, warmth. He soon finds hope in an unexpected braindance. As he and Tasha chase their dreams, their paths begin to deviate. Where will they find the happiness they've been searching for? Does it even exist to be found? One thing they can both agree on, in a place like Night City--you run, you fight, you change, or you die. Written by Bartosz Sztybor (CD PROJEKT RED writer and narrative manager, Witcher: Fading Memories)) with art by Filipe Andrade (Old Man Logan, Rocket Raccoon & Groot) and Alessio Fioriniello (Paris Fashion Slam) comes a tale about the demanding life of Night City--where lives are lost, dreams are shattered, and hope is found in what remains.
