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Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secreti...
An insider's view of court life during the Renaissance, here is the handiwork of a 16th-century diplomat who was called upon to resolve the differences in a war of etiquette among the Italian nobility.
Using Mies' writings the author presents a reconstruction of the metaphysical and philosophical inquiry upon which he based his modernism. It aims to present an integrated view of Mies' philosophy of building including his American career.
Written by leading scholars in the field, Causes of War provides the first comprehensive analysis of the leading theories relating to the origins of both interstate and civil wars. Utilizes historical examples to illustrate individual theories throughout Includes an analysis of theories of civil wars as well as interstate wars -- one of the only texts to do both Written by two former International Studies Association Presidents
In 1789 the West Indian colony of San Domingo supplied two-thirds of the overseas trade of France. The entire structure of what was arguably the most profitable colony in the world rested on the labour of half a million slaves. In 1791 the waves of unrest inspired by the French Revolution reached across the Atlantic dividing the loyalties of the white population of the island. The brutally treated slaves of Saint Domingo seized at this confusion and rose up in rebellion against masters. In thisclassic work, CLR James chronicles the only successful slave revolt in history and provides a critical portrait of their leader, Toussaint L'Ouverture, 'one of the most remarkable men of a period rich in remarkable men'.
The definitive history of modern Vietnam and its diverse and divided past