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Mathematical Modeling of Drug-induced Receptor Internalization in the HER2-positive SKBR3 Breast Cancer Cell-line
Abstract: About 20% of breast cancer tumors over-express the HER2 receptor. Trastuzumab, an approved drug to treat this type of breast cancer, is a monoclonal antibody directly binding at the HER2 receptor and ultimately inhibiting cancer cell growth. The goal of our study was to understand the early impact of trastuzumab on HER2 internalization and recycling in the HER2-overexpressing breast cancer cell line SKBR3. To this end, fluorescence microscopy, monitoring the amount of HER2 expression in the plasma membrane, was combined with mathematical modeling to derive the flux of HER2 receptors from and to the membrane. We constructed a dynamic multi-compartment model based on ordinary differe...
Cyber-Physical Security for Critical Infrastructures Protection
This book constitutes the refereed proceedings of the First International Workshop on Cyber-Physical Security for Critical Infrastructures Protection, CPS4CIP 2020, which was organized in conjunction with the European Symposium on Research in Computer Security, ESORICS 2020, and held online on September 2020. The 14 full papers presented in this volume were carefully reviewed and selected from 24 submissions. They were organized in topical sections named: security threat intelligence; data anomaly detection: predict and prevent; computer vision and dataset for security; security management and governance; and impact propagation and power traffic analysis. The book contains 6 chapters which are available open access under a CC-BY license.
Dynamic Modeling, Parameter Estimation, and Uncertainty Analysis in R
Abstract: In a wide variety of research fields, dynamic modeling is employed as an instrument to learn and understand complex systems. The differential equations involved in this process are usually non-linear and depend on many parameters whose values determine the characteristics of the emergent system. The inverse problem, i.e., the inference or estimation of parameter values from observed data, is of interest from two points of view. First, the existence point of view, dealing with the question whether the system is able to reproduce the observed dynamics for any parameter values. Second, the identifiability point of view, investigating invariance of the prediction under change of parame...
A Performance-based Tabular Approach for Joint Systematic Improvement of Risk Control and Resilience Applied to Telecommunication Grid, Gas Network, and Ultrasound Localization System
Abstract: Organizational and technical approaches have proven successful in increasing the performance and preventing risks at socio-technical systems at all scales. Nevertheless, damaging events are often unavoidable due to a wide and dynamic threat landscape and enabled by the increasing complexity of modern systems. For overall performance and risk control at the system level, resilience can be a versatile option, in particular for reducing resources needed for system development, maintenance, reuse, or disposal. This paper presents a framework for a resilience assessment and management process that builds on existing risk management practice before, during, and after potential and real e...
Design, Simulation and Performance Evaluation of a Risk-based Border Management System
Abstract: Border control systems at Europe's Schengen (and worldwide) borders are necessary to mitigate cross-border threats, but are perceived as free-traveling bottlenecks. Today's applicable European regulations demand rule-based control schemes and do not allow risk-based elements. A policy shift towards risk-based border control has been considered in several studies and research (including HEU projects). However, there is a lack of scientific evidence on how they compare with existing rule-based schemes. This paper aims to fill that gap. The simulation allows design of a realistic border control system. The passenger flow is modeled via travelers with good and bad intents. The border c...
Technical Safety, Reliability and Resilience
This book provides basics and selected advanced insights on how to generate reliability, safety and resilience within (socio) technical system developments. The focus is on working definitions, fundamental development processes, safety development processes and analytical methods on how to support such schemes. The method families of Hazard Analyses, Failure Modes and Effects Analysis and Fault Tree Analysis are explained in detail. Further main topics include semiformal graphical system modelling, requirements types, hazard log, reliability prediction standards, techniques and measures for reliable hardware and software with respect to systematic and statistical errors, and combination options of methods. The book is based on methods as applied during numerous applied research and development projects and the support and auditing of such projects, including highly safety-critical automated and autonomous systems. Numerous questions and answers challenge students and practitioners.
