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Cerebral Amyloid Angiopathy in Alzheimer’s Disease and Related Disorders
Cerebral amyloid angiopathy (CAA) is a distinctive abnormality of small cerebral blood vessels, one that has intrigued neuroscientists for decades. The time seems right for a book which examines the phenomenon of CAA using a multifaceted approach: What does it produce clinically? How might CAA be imaged? What are the crucial biochemical/cellular events within cerebral vessel walls that lead to CAA? How can in vitro or transgenic experimental systems be used to understand the etiology of, or even potential treatments for, CAA? The editors have assembled key figures in the field of CAA research to examine these (and other) questions in a series of focused chapters that address specific issues of importance in understanding CAA and its clinical manifestations. Comprehending the biology and pathogenesis of this fascinating vascular lesion may even provide clues to less common forms of cerebral microvascular disease that have been recognized for decades (hypertensive microangiopathy) or more recently (CADASIL).
Geological Magazine
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Biomarkers for Traumatic Brain Injury
Due to injuries sustained in sports and in combat, interest in traumatic brain injury (TBI) has never been greater. This book will fulfill a gap in understanding of what is occurring in the brain following injury that can subsequently be detected in biological fluids and imaging.
Sea-Changes
These ten studies provide a view of the extent to which intellectual and literary life in Holland has been influenced by English ideas. The book concludes with an overview of Anglo-Dutch cultural transfer from the early seventeenth century to the late nineteenth century, concentrating on what, between Sir Thomas Browne's stay in Leiden in 1633 and L.A.J. Burgersdijk's complete translation of Shakespeare in the 1880s, was transmitted, what sea-changes: occurred during the voyage, and in how far these resulted in something rich and strange: . The emphasis in some of the essays is on intellectual, or scholarly, contacts -- with Holland mostly on the receiving end, but by no means exclusively so...
Manual of Molecular and Clinical Lab Immunology
Introduces new material that reflects the significant advances and developments in the field of clinical laboratory immunology. • Provides a comprehensive and practical approach to the procedures underlying clinical immunology testing. • Emphasizes molecular techniques used in the field of laboratory immunology. • Updates existing chapters and adds significant new material detailing molecular techniques used in the field. • Presents guidelines for selecting the best procedures for specific situations and discusses alternative procedures. • Covers aspects of immunology related disciplines such as allergy, autoimmune diseases, cancers, and transplantation immunology.
Case Studies in Neuroanesthesia and Neurocritical Care
The anesthetic considerations and procedures involved in the perioperative care of the neurosurgical patient are among the most complex in anesthesiology. The practice of neurosurgery and neuroanesthesiology encompasses a wide range of cases, from major spine surgery, to aneurysm clipping and awake craniotomy. Case Studies in Neuroanesthesia and Neurocritical Care provides a comprehensive view of real-world clinical practice. It contains over 90 case presentations with accompanying focussed discussions, covering the broad range of procedures and monitoring protocols involved in the care of the neurosurgical patient, including preoperative and postoperative care. The book is illustrated throughout with practical algorithms, useful tables and examples of neuroimaging. Written by leading neuroanesthesiologists, neurologists, neuroradiologists and neurosurgeons from the University of Michigan Medical School and the Cleveland Clinic, these clear, concise cases are an excellent way to prepare for specific surgical cases or to aid study for both written and oral board examinations.
Biomarkers of Brain Injury and Neurological Disorders
This book explores the recent advances in the techniques and platforms used in biomarker research that have revolutionized the way we study, diagnose, and treat brain injury conditions. The contributors describe different biomarker studies pertaining to brain injury and other neurological disorders and analyze the different models and technologies used to identify these biological markers. The book includes findings from "Omics research" that have been utilized to decipher and identify such biomarkers. It discusses protein, microRNA, and altered gene profiles and reviews neurological disorders such as multiple sclerosis, Charcot-Marie-Tooth disease, and prion and Alzheimer’s disease.
Animal Models for Neurodegenerative Disease
In recent years, medical developments have resulted in an increase in human life expectancy. The editors have extensive knowledge and experience in this field and the book is aimed at undergraduates, postgraduates, and academics. The chapters cover Alzheimer's disease, Parkinson's disease, Huntington's, and other neurodegenerative disorders.
Biomateriomics
Biomateriomics is the holistic study of biological material systems. While such systems are undoubtedly complex, we frequently encounter similar components -- universal building blocks and hierarchical structure motifs -- which result in a diverse set of functionalities. Similar to the way music or language arises from a limited set of music notes and words, we exploit the relationships between form and function in a meaningful way by recognizing the similarities between Beethoven and bone, or Shakespeare and silk. Through the investigation of material properties, examining fundamental links between processes, structures, and properties at multiple scales and their interactions, materiomics ...
