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A Multi-layered Quantitative in Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes
Abstract: Damage to and loss of glomerular podocytes has been identified as the culprit lesion in progressive kidney diseases. Here, we combine mass spectrometry-based proteomics with mRNA sequencing, bioinformatics, and hypothesis-driven studies to provide a comprehensive and quantitative map of mammalian podocytes that identifies unanticipated signaling pathways. Comparison of the in vivo datasets with proteomics data from podocyte cell cultures showed a limited value of available cell culture models. Moreover, in vivo stable isotope labeling by amino acids uncovered surprisingly rapid synthesis of mitochondrial proteins under steady-state conditions that was perturbed under autophagy-deficient, disease-susceptible conditions. Integration of acquired omics dimensions suggested FARP1 as a candidate essential for podocyte function, which could be substantiated by genetic analysis in humans and knockdown experiments in zebrafish. This work exemplifies how the integration of multi-omics datasets can identify a framework of cell-type-specific features relevant for organ health and disease
Advances in Soft Computing
The two-volume set LNAI 10061 and 10062 constitutes the proceedings of the 15th Mexican International Conference on Artificial Intelligence, MICAI 2016, held in Cancún, Mexico, in October 2016. The total of 86 papers presented in these two volumes was carefully reviewed and selected from 238 submissions. The contributions were organized in the following topical sections: Part I: natural language processing; social networks and opinion mining; fuzzy logic; time series analysis and forecasting; planning and scheduling; image processing and computer vision; robotics. Part II: general; reasoning and multi-agent systems; neural networks and deep learning; evolutionary algorithms; machine learning; classification and clustering; optimization; data mining; graph-based algorithms; and intelligent learning environments.
Advances in Computational Intelligence
The two-volume set LNAI 10061 and 10062 constitutes the proceedings of the 15th Mexican International Conference on Artificial Intelligence, MICAI 2016, held in Cancún, Mexico, in October 2016. The total of 86 papers presented in these two volumes was carefully reviewed and selected from 238 submissions. The contributions were organized in the following topical sections: Part I: natural language processing; social networks and opinion mining; fuzzy logic; time series analysis and forecasting; planning and scheduling; image processing and computer vision; robotics. Part II: general; reasoning and multi-agent systems; neural networks and deep learning; evolutionary algorithms; machine learning; classification and clustering; optimization; data mining; graph-based algorithms; and intelligent learning environments.
Linguistic Methods Under Fuzzy Information in System Safety and Reliability Analysis
This book reviews and presents a number of approaches to Fuzzy-based system safety and reliability assessment. For each proposed approach, it provides case studies demonstrating their applicability, which will enable readers to implement them into their own risk analysis process. The book begins by giving a review of using linguistic terms in system safety and reliability analysis methods and their extension by fuzzy sets. It then progresses in a logical fashion, dedicating a chapter to each approach, including the 2-tuple fuzzy-based linguistic term set approach, fuzzy bow-tie analysis, optimizing the allocation of risk control measures using fuzzy MCDM approach, fuzzy sets theory and human reliability, and emergency decision making fuzzy-expert aided disaster management system. This book will be of interest to professionals and researchers working in the field of system safety and reliability, as well as postgraduate and undergraduate students studying applications of fuzzy systems.
The Boundaried Therapist
Set boundaries to sustain yourself and your counselling practice Setting healthy boundaries. It’s a central theme in many counselling sessions, yet something that therapists often struggle to do for themselves. In a profession that is motivated by a desire to help others and relieve suffering, the pressure is always there for therapists to put others’ needs before their own. For registered psychologist Nicole Perry, the conversation around therapists’ own needs is conspicuously missing. When these needs are not addressed, therapists are left vulnerable to potential career- and life-altering outcomes like burnout and vicarious trauma. It’s time to think about boundaries that contemplate the therapist in a wholistic way, addressing not only their professional responsibilities, but their limits, needs, and values. Taking a somatic and feminist approach, Nicole leads readers down a self-reflective path to practical boundaries that nurture them as people first, therapists second: boundaries that are essential for building and sustaining a long and vibrant career in counselling.
Computational Science and Its Applications - ICCSA 2007
This three-volume set constitutes the refereed proceedings of the International Conference on Computational Science and its Applications. These volumes feature outstanding papers that present a wealth of original research results in the field of computational science, from foundational issues in computer science and mathematics to advanced applications in almost all sciences that use computational techniques.
