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Ni�os, j�venes y adolescentes: ellas, ellos y su m�vil
Los cambios sociales y tecnológicos que se están produciendo en los últimos años, influyen en las relaciones interpersonales, especialmente en las edades más tempranas y en la adolescencia. Como resultado de la presencia actual y predominante de los dispositivos móviles (ya sean teléfonos, tablets o pantallas, entre otros medios digitales) en la sociedad moderna, los docentes y las familias deben comenzar a dialogar sobre el uso adecuado de los mismos, así como de los valores éticos y ciudadanos que se proyectan hacia los niños y jóvenes. Porque la adquisición de dispositivos móviles, en las escuelas y en el hogar, presupone una aceptación tácita de los riesgos que ello puede generar.
Strategies in the drug discovery and development for leishmaniasis: immunomodulators, natural products, synthetic compounds, and drug repositioning
Leishmaniases are a group of tropical diseases that affect millions of people worldwide. They are considered neglected diseases prevalent in emerging countries in Latin America, West Africa, and Southeast Asia and still occurring in Mediterranean countries. There is no human vaccine available to prevent and control the disease infection. For the last 70 years, the available chemotherapy has been constituted by first-line (pentavalent antimonials) and second-line drugs (amphotericin B, pentamidine, paramomycin, and miltefosine). Its route of administration is difficult, the treatment is long, and its efficiency varies depending on the parasite species and clinical manifestations, which results in the emergence of resistant cases. Moreover, they present high toxicity to patients, and even some less toxic formulations available, are still expensive for the poorest countries’ vulnerable populations. This often leads to abandonment and failure of treatment. The medical-scientific community is facing difficulties to overcome these issues with new suitable therapies, and the identification of new drug targets. So, it means that efforts to identify new strategies must continue.
Index Medicus
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Exame
None
Diario Oficial
Laws, decrees, and administrative acts of government.
Diário Oficial
None
The Atlantic Forest of South America
This is a detailed assessment of the state of biodiversity in the Atlantic Forest. Separate sections examine each of the three countries that are home to the forest, beginning with a brief overview that explores the dynamics of biodiversity loss in that country and outlining the topics to be addressed.
