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Strategies in the drug discovery and development for leishmaniasis: immunomodulators, natural products, synthetic compounds, and drug repositioning
Leishmaniases are a group of tropical diseases that affect millions of people worldwide. They are considered neglected diseases prevalent in emerging countries in Latin America, West Africa, and Southeast Asia and still occurring in Mediterranean countries. There is no human vaccine available to prevent and control the disease infection. For the last 70 years, the available chemotherapy has been constituted by first-line (pentavalent antimonials) and second-line drugs (amphotericin B, pentamidine, paramomycin, and miltefosine). Its route of administration is difficult, the treatment is long, and its efficiency varies depending on the parasite species and clinical manifestations, which results in the emergence of resistant cases. Moreover, they present high toxicity to patients, and even some less toxic formulations available, are still expensive for the poorest countries’ vulnerable populations. This often leads to abandonment and failure of treatment. The medical-scientific community is facing difficulties to overcome these issues with new suitable therapies, and the identification of new drug targets. So, it means that efforts to identify new strategies must continue.
Talk and Social Theory
Talk and Social Theory will be an essential text for students of sociolinguistics and the analysis of discourse in conversation. introduces the study of 'talk' linked to social theory; develops a new theoretical argument that reviews the relations between local social practices and general societal processes of talk; the use of everyday examples - a family dinner table, a school classroom, an academic advising session in an community college - enhances the book’s appeal to a non-specialist as well as a specialist audience; reviews the key theoretical perspectives and conceptual frameworks in social theory and in the sociolinguistic study of talk.
Fieldwork in Educational Settings
This new edition brings original, best-selling text right up-to-date for new researchers and includes a new chapter on computer software for data handling.
Heráclito Fontoura Sobral Pinto
Na formação de Sobral Pinto há de se destacar de início o aspecto pouco ressaltado entre nós, o da mobilidade social em nosso país. De família modesta, pai ferroviário, ascende, graças aos estudos e às suas características pessoais, à posição de destaque que obteve na vida brasileira. De sua formação pode-se também destacar a origem mineira com características de rígidos princípios e de religiosidade.
Almanaque
None
Expressões acadêmicas e dialógos sobre migração, refúgio e políticas sociais
Esta obra congrega resultados de pesquisas e estudos realizados por professores e acadêmicos de diversas áreas de conhecimento a respeito das migrações e refúgio, sob a perspectiva atual das políticas públicas e sociais no campo das desigualdades sociais vigentes na sociedade capitalista de hoje. A coletânea propõe continuidade das discussões apresentadas no livro I.
Challenges of Human Rights in Latin America
Latin America offers a democratic and constitutional process, with the goals to respect fundamental human rights and control the excess of power. Nevertheless, the weaknesses of the rule of law’s institutions does not guarantee for all citizens the protection of old and new rights. In this sense, the Inter-American Fundamental Rights Conference organized by the Inter-American Network on Fundamental Rights and Democracy (RED–IDD) is an annual meeting of professors and researchers from the different universities of Latin America, addressing topics of particular importance regarding the possibilities and challenges of the consolidation of the constitutional state in the region. This book presents the minutes of the Fourth Inter-American Fundamental Rights Conference, and explores topics such as political rights and the consolidation of democracy in Latin America; impeachment and judicial guarantees; the challenges of freedom of information: and judicial protection and due process, amongst others.
Future Visions
None
Frontiers in Synaptic Plasticity: Dendritic Spines, Circuitries and Behavior
The term “synaptic plasticity” is a broad concept, which is studied with a variety of experimental approaches. One focus is the impact of changes in synaptic, neuronal and glial morphology on brain circuitry and behavior. In this regard, unique animal models have been key to the study of affective and social behaviors and neurological and psychiatric diseases. However, there is a paucity of compilations directed toward the correlation of alterations in synaptic structure with various physiological and behavioral paradigms. This Frontiers Research Topic will, therefore, serve as an exciting forum for the exchange of novel hypotheses and data and an important resource and reference for investigators studying synaptic and brain plasticity, as well as those in related fields.
