Welcome to our book review site go-pdf.online!
You may have to Search all our reviewed books and magazines, click the sign up button below to create a free account.
Perspectives for Novel Therapeutic Concepts in Hepatocellular Carcinoma Targeting the Stromal and Innate Immune Microenvironment
Abstract: Hepatocellular carcinoma (HCC) is a major public health burden with increasing incidence and mortality worldwide. Arising almost exclusively on the background of chronic liver disease, the tumour microenvironment plays a tremendous role in the occurrence and progression of HCC. With the emergence of checkpoint inhibitor-based combination therapies as first-line therapy in advanced HCC, the tumour microenvironment has drawn increasing attention as a target for novel therapeutic approaches. In fact, checkpoint-inhibitor-based immunotherapies currently dominate clinical studies on HCC therapy. Importantly, whilst checkpoint-inhibitor-based immune-oncology primarily targets T-cells, th...
Prediction of Postembolization Syndrome After Transarterial Chemoembolization of Hepatocellular Carcinoma and Its Impact on Prognosis
Abstract: Background: Postembolization syndrome (PES) represents the most frequent complication after transarterial chemoembolization (TACE) in patients with HCC. Given the vague definition as a symptom complex comprising abdominal pain, fever, and nausea, PES is diagnosed in heterogeneous patient cohorts with symptoms ranging from mild pain to severe deterioration of their general condition. This study aimed to evaluate predictive factors and the prognostic impact of PES with regard to different severity grades. Methods: A total of 954 patients treated with TACE for HCC at the University Medical Centres Mainz and Freiburg were included in this study. PES disease severity was graded as mild,...
Tight Junction Protein Signaling and Cancer Biology
Abstract: Tight junctions (TJs) are intercellular protein complexes that preserve tissue homeostasis and integrity through the control of paracellular permeability and cell polarity. Recent findings have revealed the functional role of TJ proteins outside TJs and beyond their classical cellular functions as selective gatekeepers. This is illustrated by the dysregulation in TJ protein expression levels in response to external and intracellular stimuli, notably during tumorigenesis. A large body of knowledge has uncovered the well-established functional role of TJ proteins in cancer pathogenesis. Mechanistically, TJ proteins act as bidirectional signaling hubs that connect the extracellular co...
Survival Prediction Using the Freiburg Index of Post-TIPS Survival (FIPS) in Critically Ill Patients with Acute- on Chronic Liver Failure: A Retrospective Observational Study
Abstract: Background and aim: Liver cirrhosis in patients treated in the intensive care unit (ICU) is associated with high mortality. Well established scores are useful to allow for assessment of prognosis and support ICU treatment guidance. However, currently used scoring systems often do not reflect the complexity of critically ill patients. Therefore, we tested the newly developed Freiburg index-of post-TIPS survival (FIPS) score in order to assess its potential role for prognostication of cirrhotic patients in the ICU. Methods: A total of 310 patients with liver cirrhosis treated in the ICU between 2010 and 2021 were enrolled in this retrospective observational study. Prognostic factors ...
Ectopic Papillary Thyroid Carcinoma Within a Thyroglossal Duct Cyst
Abstract: Rationale: Ectopic thyroid carcinoma within a thyroglossal duct cyst (TGDCCa) is an extremely rare entity. Thus, there is no unified appropriate therapeutic strategy, and individual approaches are controversial. Patients concerns: We report the case of a 21-year old woman who underwent Sistrunk procedure for a thyroglossal duct cyst (TGDC). Diagnoses: During histological evaluation of the resected TGDC a papillary thyroid carcinoma was found. Interventions: Due to a tumor size of 1cm and proximity to the surgical border, Sistrunk procedure was extended by total thyroidectomy, followed by radioiodine ablation. Outcomes: Except of minimal follicular hyperplasia, the histological exam...
Antisemitism in the North
Is research on antisemitism even necessary in countries with a relatively small Jewish population? Absolutely, as this volume shows. Compared to other countries, research on antisemitism in the Nordic countries (Denmark, the Faroe Islands, Finland, Greenland, Iceland, Norway, and Sweden) is marginalized at an institutional and staffing level, especially as far as antisemitism beyond German fascism, the Second World War, and the Holocaust is concerned. Furthermore, compared to scholarship on other prejudices and minority groups, issues concerning Jews and anti-Jewish stereotypes remain relatively underresearched in Scandinavia – even though antisemitic stereotypes have been present and flourishing in the North ever since the arrival of Christianity, and long before the arrival of the first Jewish communities. This volume aims to help bring the study of antisemitism to the fore, from the medieval period to the present day. Contributors from all the Nordic countries describe the status of as well as the challenges and desiderata for the study of antisemitism in their respective countries.
Single Windows and Trade Facilitation
Présentation de l'éditeur : " The Single Windows electronic environment, introduced as part of the World Trade Organization's Agreement on Trade Facilitation (ATF) in December 2013, promises to bring meaningful gains to all parties involved in cross-border commerce. The main value proposition for having a single window for a country or economy is to increase the efficiency through time and cost savings for traders in their dealings with government authorities for obtaining the relevant clearance and permit(s) for moving cargoes across national or economic borders. However, a common view in developing countries is that the system's implementation costs far outweigh its presumed (and questio...
Autumn Glory
A suspenseful account of the glorious days more than a century ago when our national madness began, the first Major League Baseball World Series. A post-season series of games to establish supremacy in the major leagues was not inevitable in the baseball world. But in 1903 the owner of the Pittsburgh Pirates (in the well-established National League) challenged the Boston Americans (in the upstart American League) to a play-off, which he was sure his team would win. They didn't—and that wasn't the only surprise during what became the first World Series. In Autumn Glory, Louis P. Masur tells the riveting story of two agonizing weeks in which the stars blew it, unknown players stole the show,...
