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The Physics of Cancer
An introduction to the emerging field of cancer physics, integrating cancer biology with approaches from theoretical and applied physics.
Copper-Mediated Cross-Coupling Reactions
Providing comprehensive insight into the use of copper in cross-coupling reactions, Copper-Mediated Cross-Coupling Reactions provides a complete up-to-date collection of the available reactions and catalytic systems for the formation of carbon-heteroatom and carbon-carbon bonds. This essential reference covers a broad scope of copper-mediated reactions, their variations, key advances, improvements, and an array of academic and industrial applications that have revolutionized the field of organic synthesis. The text also discusses the mechanism of these transformations, the use of copper as cost-efficient alternative to palladium, as well as recently developed methods for conducting copper-mediated reactions with supported catalysts.
Fragment-Based Drug Discovery
Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is hoped that this approval is just the beginning of the many drugs yet to be discovered using this fascinating technique. This book is written from a Chemist's perspective and comprehensively assesses the impact of fragment-based drug discovery on a wide variety of areas of medicinal chemistry. It will prove to be an invaluable resource for medicinal chemists working in academia and industry, as well as anyone interested in novel drug discovery techniques.
Musculoskeletal Infection
This text provides a guide to understanding the mechanisms involved in the pathogenesis of muscoskeletal sepsis. It covers areas such as bone, cartilage, soft tissue, and biomaterial interaction in the face of infection.
Bioterrorism and Biocrimes
During the past five years, the threat of bioterrorism has become a subject of widespread concern. Journalists, academics, and policy analysts have considered the subject, and in most cases found much to alarm them. Most significantly, it has captured the attention of policy makers at all levels of government in the United States. Unfortunately, bioterrorism remains a poorly understood subject. Many policymakers and policy analysts present apocalyptic visions of the threat, contending that it is only a matter of time before some terrorist uses biological agents to cause mass casualties. In contrast, other analysts argue that the empirical record provides no basis for concern, and thus largel...
Diseases of the Chest, Breast, Heart and Vessels 2019-2022
This open access book focuses on diagnostic and interventional imaging of the chest, breast, heart, and vessels. It consists of a remarkable collection of contributions authored by internationally respected experts, featuring the most recent diagnostic developments and technological advances with a highly didactical approach. The chapters are disease-oriented and cover all the relevant imaging modalities, including standard radiography, CT, nuclear medicine with PET, ultrasound and magnetic resonance imaging, as well as imaging-guided interventions. As such, it presents a comprehensive review of current knowledge on imaging of the heart and chest, as well as thoracic interventions and a selection of "hot topics". The book is intended for radiologists, however, it is also of interest to clinicians in oncology, cardiology, and pulmonology.
Click Chemistry in Glycoscience
Lays the foundation for new methods and applications of carbohydrate click chemistry Introduced by K. Barry Sharpless of The Scripps Research Institute in 2001, click chemistry mimics nature, giving researchers the tools needed to generate new substances quickly and reliably by joining small units together. With contributions from more than thirty pioneering researchers in the field, this text explores the many promising applications of click chemistry in glycoscience. Readers will learn both the basic concepts of carbohydrate click chemistry as well as its many biomedical applications, including synthetic antigens, analogs of cell-surface receptors, immobilized enzymes, targeted drug delive...
The Mystery of Life's Origin
The origin of life from non-life remains one of the most enduring mysteries of modern science. This book investigates how close scientists are to solving that mystery and explores what we are learning about the origin of life from current research in chemistry, physics, astrobiology, biochemistry, and more.
