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Major Histocompatibility Complex (MHC) in Health and Disease
The major histocompatibility complex (MHC) is a highly polymorphic and diverse multigene locus in all jawed vertebrate species that has an integral role in adaptive/innate immune systems, transplantation, and infectious and autoimmune diseases. The MHC supra-locus in mammalian vertebrates is usually partitioned into three distinct regions, known as classes I, II, and III, which, to varying extents, can be found conserved in nonmammalian jawed vertebrates, such as bony fish, amphibians, and bird lineages. The MHC gene region is characterized particularly by the expression of class I and class II glycoproteins that bind peptides derived from intracellular or extracellular antigens to circulati...
Brainology
Ever wondered how people cope with 24-hour darkness or if smartphones make children stupid? Have you heard about the US plan to supercharge minds? Originally written for the Wellcome charity, these 16 stories explore the mysteries of the human brain. Learn about everything from the science of pain to VR surgery to the therapeutic quality of LSD. Contents Ouch! The science of painWhy doctors are reclaiming LSD and ecstasyInside the mind of an interpreterHow should we deal with dark winters?Smartphones won’t* make your kids dumb (*Probably)You can train your mind into ‘receiving’ medicineCharting the phenomenon of deep griefThe mirror cure for phantom limb painCan you think yourself into a different person?How to survive a troubled childhoodWhat tail-chasing dogs reveal about humansA central nervous solution to arthritisCould virtual reality headsets relieve pain?What it means to be homesick in the 21st CenturyLighting up brain tumours with Project VioletThe US military plan to supercharge brains
Sex-associated Differences in Cytomegalovirus Prevention: Prophylactic Strategy is Potentially Associated with a Strong Kidney Function Impairment in Female Renal Transplant Patients
Abstract: Post-transplantation cytomegalovirus (CMV) syndrome can be prevented using the antiviral drug (val)ganciclovir. (Val)ganciclovir is typically administered following a prophylactic or a pre-emptive strategy. The prophylactic strategy entails early universal administration, the pre-emptive strategy, early treatment in case of infection. However, it is not clear which strategy is superior with respect to transplantation outcome; sex-specific effects of these prevention strategies are not known. We have retrospectively analyzed 540 patients from the multi-centre Harmony study along eight pre-defined visits: 308 were treated according to a prophylactic, 232 according to a pre-emptive st...
Cure
THE NEW YORK TIMES BESTSELLER SHORTLISTED FOR THE ROYAL SOCIETY SCIENCE BOOK PRIZE LONGLISTED FOR THE WELLCOME PRIZE ALL IN THE MIND? - Can meditation fend off dementia? - Can the smell of lavender affect the immune system? - Can your thoughts ease physical pain? In Cure, award-winning science writer Jo Marchant travels the world to meet the physicians, patients and researchers on the cutting edge of mind-body medicine. Asking how the brain can heal the body and how we can all make changes to keep ourselves healthier.
