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Next Generation Sequencing
Next generation sequencing (NGS) has surpassed the traditional Sanger sequencing method to become the main choice for large-scale, genome-wide sequencing studies with ultra-high-throughput production and a huge reduction in costs. The NGS technologies have had enormous impact on the studies of structural and functional genomics in all the life sciences. In this book, Next Generation Sequencing Advances, Applications and Challenges, the sixteen chapters written by experts cover various aspects of NGS including genomics, transcriptomics and methylomics, the sequencing platforms, and the bioinformatics challenges in processing and analysing huge amounts of sequencing data. Following an overview of the evolution of NGS in the brave new world of omics, the book examines the advances and challenges of NGS applications in basic and applied research on microorganisms, agricultural plants and humans. This book is of value to all who are interested in DNA sequencing and bioinformatics across all fields of the life sciences.
Major Histocompatibility Complex (MHC) in Health and Disease
The major histocompatibility complex (MHC) is a highly polymorphic and diverse multigene locus in all jawed vertebrate species that has an integral role in adaptive/innate immune systems, transplantation, and infectious and autoimmune diseases. The MHC supra-locus in mammalian vertebrates is usually partitioned into three distinct regions, known as classes I, II, and III, which, to varying extents, can be found conserved in nonmammalian jawed vertebrates, such as bony fish, amphibians, and bird lineages. The MHC gene region is characterized particularly by the expression of class I and class II glycoproteins that bind peptides derived from intracellular or extracellular antigens to circulati...
The Anthropocene Cookbook
More than sixty speculative art and design projects explore how art, food, and creative thinking can prepare us for future catastrophes. In the Age of the Anthropocene—an era characterized by human-caused climate disaster—catastrophes and dystopias loom. The Anthropocene Cookbook takes our planetary state of emergency as an opportunity to seize the moment to imagine constructive change and new ideas. How can we survive in an age of constant environmental crises? How can we thrive? The Anthropocene Cookbook answers these questions by presenting a series of investigative art and design projects that explore how art, food, and creative thinking can prepare us for future catastrophes. This c...
Biochemical Actions of Hormones V11
Biochemical Actions of Hormones, Volume XI is a 12-chapter text that covers the general and specific biochemical aspects of polypeptide and steroid hormones. The introductory chapters deal with the biochemical actions of the leukotrienes, the cyclic adenosine monophosphate, and the gonadotropin releasing hormone. The next chapters highlight detailed contributions on polypeptide hormone research. These chapters specifically tackle the insulin actions and the role of insulin in mammary gland development. The last series of chapters on steroid hormones includes X-ray crystallographic analysis of steroid structures and the significance of these studies on steroid-receptor interactions. These chapters also explore the analysis of the estrogen receptor with monoclonal antibodies; the role of estrogen receptor in responsive mammalian cells; the use of peroxidase as a marker of catechol estrogen action; and the activation and stabilization of the glucocorticoid receptor. This volume will be of great benefit to biochemists, biologists, endocrinologists, and researchers who are interested in the hormonal action and regulation.
Adriatic
Adriatic recounts the shared history of the countries around the sea, from Italy to Croatia and beyond, from the Romans to the present.
Neuroinflammation, Neurodegeneration and Metabolic Disease: From Molecular Mechanisms to Therapeutic Innovation
Neuroinflammation manifests as changes to cognition or behavior, or as altered function in peripheral tissues. Patients with metabolic diseases (e.g., diabetes, obesity) are more likely to suffer with neuroinflammation since the disrupted metabolism and chronic low-grade inflammation that accompany metabolic diseases extends to the nervous system. Neuroinflammation will then lead to functional impairment and progressive loss of neuronal structure, with neurodegeneration being the end result. Factors like chronic hyperglycemia, dyslipidemia and insulin resistance are candidate drivers of neuroinflammation and neurodegeneration. The effects on the nervous system also contribute to worsening in...
Major Histocompatibility Complex
Every biological system is the outcome of evolution and has a history all its own. This history dictates how the system works and why it has certain properties and not others. This is why we need to study not only the structure and function, but also the history of the system. This argument undoubtedly applies to the study of the immune system and also to the study of the major histocompatibility complex (MHC). Since 1989, researchers of various scientific disciplines who share a deep inter est in MHC evolution have held a meeting every two years to discuss their latest research developments, exchange ideas, and foster friendship. Together with my colleagues Drs. Naoyuki Takahata and Yoko Sa...
HLA and Associated Important Diseases
This year marks the 60th anniversary of HLA discovery by the French Nobel laureate physician Jean Dausset, as well as the 55th anniversary of the identification and naming of the first HLA. Under such circumstances, both basic HLA research and its clinical applications need a new book that comprehensively reflects the latest achievements in the field. Thus, Professor Xi as Editor has contributed to organize international experts in the areas of HLA-related basic research and clinical applications, to unite their knowledge in chapters covering various related topics, and finally to finish the book "HLA and Associated Important Diseases". The book consists of three sections which mainly include basic theoretical and technological developments, several important HLA-associated autoimmune diseases and HLA-associated infectious diseases.
Fault Lines
What is the link, if any, between race and disease? How did the term baster as ‘mixed race’ come to be mistranslated from ‘incest’ in the Hebrew Bible? What are the roots of racial thinking in South African universities? How does music fall on the ear of black and white listeners? Are new developments in genetics simply a backdoor for the return of eugenics? For the first time, leading scholars in South Africa from different disciplines take on some of these difficult questions about race, science and society in the aftermath of apartheid. This book offers an important foundation for students pursuing a broader education than what a typical degree provides, and a must-read resource for every citizen concerned about the lingering effects of race and racism in South Africa and other parts of the world.
