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Secukinumab in Enthesitis-related Arthritis and Juvenile Psoriatic Arthritis: a Randomised, Double-blind, Placebo-controlled, Treatment Withdrawal, Phase 3 Trial
Abstract: Background Treatment options in patients with enthesitis-related arthritis (ERA) and juvenile psoriatic arthritis (JPsA) are currently limited. This trial aimed to demonstrate the efficacy and safety of secukinumab in patients with active ERA and JPsA with inadequate response to conventional therapy. Methods In this randomised, double-blind, placebo-controlled, treatment-withdrawal, phase 3 trial, biologic-naïve patients (aged 2 to 18 years) with active disease were treated with open-label subcutaneous secukinumab (75/150 mg in patients 50/≥50 kg) in treatment period (TP) 1 up to week 12, and juvenile idiopathic arthritis (JIA) American College of Rheumatology 30 responders at w...
JIMD Reports, Volume 25
JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.
Current Opinions in Pediatric Rheumatology
The aim of this book is to be a guide to general practitioners and paediatricians under the light of the current concepts. It will not only help the reader to understand the pathogenesis of common childhood rheumatic diseases, but also provide the general practitioners with a current algorithm that will help them to decide what to do and when to seek reference. It is the child with arthritis, recurrent fever, or a non-specific rash that is a diagnostic dilemma, and that is waiting for someone to solve the problem. For this reason, this book includes real case histories with their photos, radiographic findings, and further investigations, where necessary.
Rare Causes of Stroke
This user-friendly, practical book guides readers on the diagnosis of rare causes of stroke to improve patient outcomes.
Health Economics Disparities, Inequality and Inequity In Healthcare Services: Today's Reality and Tomorrow's Challenges
The principle of equality is the ideological basis for the public healthcare system in most Western countries. Equality in availability of and access to healthcare services is an essential condition for fulfilling the “patient-centered” perspective that prevails today in many healthcare systems around the world. Equality in health, in its various aspects, is a value to which many aspire, although some extent of inequality and health will always exist. Since some disparities in health are unavoidable and individuals are free to live as they wish, there will always be gaps among population groups in their abilities and willingness to invest in their health.
