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Metalloprotein Active Site Assembly
Summarizes the essential biosynthetic pathways for assembly of metal cofactor sites in functional metalloproteins Metalloprotein Active Site Assembly focuses on the processes that have evolved to orchestrate the assembly of metal cofactor sites in functional metalloproteins. It goes beyond the simple incorporation of single metal ions in a protein framework, and includes metal cluster assembly, metal-cofactor biosynthesis and insertion, and metal-based post-translational modifications of the protein environments that are necessary for function. Several examples of each of these areas have now been identified and studied; the current volume provides the current state-of-the-art understanding ...
Optogenetics
This book provides applications for the revolutionary technique of optogenetics, which combines genetic and optical methods to observe the function of neurons.
Transition Metals and Sulfur – A Strong Relationship for Life
Metal-Sulfur clusters play an essential role in living organisms through the unique character of sulfur-metal bonding. The new volume in prestigious Metal Ions in Life Sciences explores different transition metal complexes with sulfur, their biosynthesis and biological functions in regulation of gene expression, catalysis of important metabolic reactions and protein structure arrangement.
Opsin-free Optogenetics
Optogenetics represents a breakthrough technology capable of dynamically modulating molecular and cellular activity in live cells with high precision. This transformative technology made it possible to reversibly interrogate protein actions, cellular events, and animal behaviors with a simple flash of light. Manipulating the temporal and spatial profile of light enabled precise control of membrane potentials. This feature has inspired non-opsin-based optogenetics, which not only inherits the precise spatiotemporal resolution but also expands the targets into a diverse pool of biomolecules such as membrane receptors, ion channels, kinases, GTPases, and transcription factors. This book is uniq...
Microbial Stress: From Sensing to Intracellular and Population Responses
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Die Jahre des Maulwurfs
Von der Tragik, aber auch der Komik des Aufwachsens in der tiefen Provinz – ein virtuoses literarisches Debüt! Die Erzählerin weiß nicht, ob ein Fest oder eine Beerdigung sie erwartet, als sie nach vielen Jahren in ihr Heimatdorf zurückfährt. Im Gepäck hat sie nur den ausgestopften Maulwurf Herrn Klotho – das Einzige, was geblieben ist von ihrer wundersamen Freundin Tanja, mit der sie vor über dreißig Jahren das Abenteuer des Erwachsenwerdens antrat. Tanja, die Rebellische, die mutig und mühelos alle Grenzen im Dorf überschritt und die Kinder zu bizarren Unternehmungen anstiftete. In der Erinnerung wird noch einmal die gemeinsame Kindheit lebendig, die die Erzählerin bis heute prägt: das Ulkige, Verrückte, Grobe des Dorfes, Bauernschläue und vor allem Tanjas magische Sicht auf die Welt. Und sie versteht jetzt, weshalb ihre Freundin damals so plötzlich verschwunden ist. Kerstin Brune legt mit großem literarischem Gespür und kraftvollen Bildern einen virtuosen Roman über zwei ungleiche Freundinnen vor. Ein Buch voller Skurrilität und Weisheit, Humor und Poesie.
Biochemistry, Biosynthesis and Human Diseases
This volume on iron-sulfur proteins includes chapters that discuss how microbes, plants, and animals synthesize these complex prosthetic groups, and why it is important to understand the chemistry and biogenesis of iron sulfur proteins. In addition to their vital importance in mitochondrial respiration, numerous iron sulfur proteins are important in maintenance of DNA integrity. Multiple rare human diseases with different clinical presentations are caused by mutations of genes in the iron sulfur cluster biogenesis pathway. Understanding iron sulfur proteins is important for understanding a rapidly expanding group of metabolic pathways important in all kingdoms of life, and for understanding processes ranging from nitrogen fixation to human disease.
Fe-S Cluster Enzymes Part B
Methods in Enzymology, Volume 599 is the second of two volumes focused on Fe-S cluster enzymes. Topics of interest in this new release include steps towards understanding mitochondrial Fe/S cluster biogenesis, iron sulfur clusters in zinc finger proteins, electrochemistry of Iron-sulfur enzymes, NRVS for Fe in biology and its experiment and basic interpretation, methods for studying iron regulatory protein 1, an important protein in human iron metabolism, the characterization of glutaredoxin Fe-S cluster binding interactions using circular dichroism spectroscopy, fluorescent reporters to track Fe-S cluster assembly and transfer reactions, methods for studying the Fe-S cluster containing base excision repair glycosylase MUTYH, and more. Contain contributions from leading authorities on enzymology Informs and updates on all the latest developments in the field
Abi Box Biologie
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