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Here are the facts, divulged in painful and deeply moving detail, and told with an intimacy that could only be disclosed by one caught in the centre of the storm.
Breast cancer remains the leading cause of cancer in women, which makes accurate diagnoses on core needle biopsy (CNB) specimens of vital importance in staging and guiding therapy decisions for patients. The first edition of this multi-authored text written by leaders in the field from major academic medical centers provided a comprehensive guide on diagnostic breast pathology in the core biopsy setting. In addition to in-depth coverage of benign and malignant entities encountered in breast core biopsies, the book provided additional resources to improve diagnostic accuracy such as pattern-based approaches to evaluation, mimickers of breast lesions arising in extra-mammary sites, and pitfall...
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Ten years on from The Woman Who Walked into Doors, Booker Prize-winning author, Roddy Doyle, returns to one of his greatest characters, Paula Spencer. Paula Spencer is turning forty-eight, and hasn’t had a drink for four months and five days. Her youngest children, Jack and Leanne, are still living with her. They're grand kids, but she worries about Leanne. Paula still works as a cleaner, but all the others doing the job seem to come from Eastern Europe. You can get a cappuccino in the café and the checkout girls are all Nigerian. Ireland is certainly changing, but then so too is Paula – dry, and determined to put her family back together again. ‘A phenomenally rewarding read... Could not be bettered in its depiction of the minutiae of the life of a recovering alcoholic: relentless, trivial, terrified’ Observer
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Programmed cell death (PCD) is central in maintaining the life of multicellular organisms, during development as well as in healthy adulthood or in the context of disease. The best understood form of PCD is apoptosis, a caspase mediated, immunologically silent cell death that can be initiated in probably all cell types upon aging, lack of growth support, critical damage or infection. One of the key pathways of apoptosis involves mitochondrial outer membrane permeabilization (MOMP), a process tightly regulated by members of the BCL-2 family. Whereas PCD and apoptosis were used synonymously in the past, other forms of PCD have been discovered more recently, including RIPK1/3- and MLKL-dependen...
Is knowledge the greatest virtue? What is it like to be somebody else? What if tomorrow never comes? Is the world around us real? Your students will be asking these challenging questions and more after reading and completing the activities in More Philosophy for Teens. A companion to the best-selling Philosophy for Teens, this volume tackles the topics of reality and knowledge in a teenager-friendly format. The authors examine some of life's toughest questions, including identity, God, the universe, freedom, and the meaning of life. Both sides of the debates are covered on every issue, with information from some of the world's most noted philosophers included in a conversational style that teenagers will love. Grades 7-12