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Paediatric drug optimization for cancer medicines
The goal of the Paediatric drug optimization for cancer exercise was to develop a PADO priority list of formulations to be prioritized with a time horizon of 3–5 years, and a PADO ‘watch list’ containing promising candidates for investigation and development for children with a time horizon of 5–10 years. The PADO–cancer exercise enables alignment between funders, procurers, market-coordination entities, researchers, innovators, generics manufacturers, product development partnerships and regulators on priority products to be investigated and developed, as well as increasing efforts to tackle challenges in access to cancer medicines in LMICs.
Paediatric Formulation
The development of paediatric medicines can be challenging since this is a different patient population with specific needs. A medicine designed for use in paediatric patients must consider the following aspects: patient population variability; the need for dose flexibility; route of administration; patient compliance; excipient tolerability. For example, the toxicity of excipients may differ in children compared to adults and children have different taste preferences. Globally, about 75% of drugs do not carry regulatory approval for use in children; worldwide, many medications prescribed for the treatment of paediatric diseases are used off-label, and less than 20% of package inserts have sufficient information for treating children. This book provides an update on both state-of-the-art methodology and operational challenges in paediatric formulation design and development. It aims at re-evaluating what is needed for more progress in the design and development of age-appropriate treatments for paediatric diseases, focusing on: formulation development; drug delivery design; efficacy, safety, and tolerability of drugs and excipients.
Recent Advances in Retinoblastoma Treatment
This book is a comprehensive resource on the current understanding of retinoblastoma. It addresses all the essential aspects of retinoblastoma and its management, including: its molecular biology and genetics, management by focal treatment, intraarterial and intravitreal chemotherapy, electroretinogram monitoring of treatment, pharmacokinetic studies, high-risk features, treatment of metastatic disease, and long-term follow-up. The book represents a collaborative project involving ophthalmic oncologists, geneticists, pediatric oncologists, interventional neuroradiologists, electrophysiologists, and basic scientists who are at the forefront of their field. It is written in an accessible manner, and a wealth of tables, figures, and exemplary images are included to enhance the understanding of concepts.
AACR 2022 Proceedings: Part B April 11-13
The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world.
VIII Latin American Conference on Biomedical Engineering and XLII National Conference on Biomedical Engineering
This book gathers the joint proceedings of the VIII Latin American Conference on Biomedical Engineering (CLAIB 2019) and the XLII National Conference on Biomedical Engineering (CNIB 2019). It reports on the latest findings and technological outcomes in the biomedical engineering field. Topics include: biomedical signal and image processing; biosensors, bioinstrumentation and micro-nanotechnologies; biomaterials and tissue engineering. Advances in biomechanics, biorobotics, neurorehabilitation, medical physics and clinical engineering are also discussed. A special emphasis is given to practice-oriented research and to the implementation of new technologies in clinical settings. The book provides academics and professionals with extensive knowledge on and a timely snapshot of cutting-edge research and developments in the field of biomedical engineering.
Colección de Propiedad Industrial e Intelectual (Vol. 3)
La presente obra aborda temas vinculados a la protección de la propiedad industrial e intelectual de los medicamentos e innovaciones en el campo de la salud, del derecho de la moda y la protección de las marcas en Latinoamérica.
Colección de propiedad industrial e intelectual (Vol. 1)
El presente volumen incluye, entre otros, los trabajos jurídicos seleccionados por la Asociación de Derechos Intelectuales, ASDIN, como los más relevantes entre los que compiten en el concurso anual organizado por esta institución. La propiedad intelectual continúa adquiriendo importancia creciente en países que, como los de Latinoamérica, han comenzado a tomar conciencia de la relevancia de impulsar la investigación científico-tecnológica, las industrias culturales y la innovación productiva. En por ello que ASDIN fomenta el estudio de la legislación, las regulaciones en la materia y apoya la observancia de los derechos y obligaciones de modo que el sistema jurídico en la región se actualice, manteniendo un adecuado equilibrio entre productores y usuarios, impulsando el desarrollo de la creatividad.
Ophthalmic Oncology
This book highlights the unique aspects of oncologic ophthalmology as a medical and surgical discipline practiced at a comprehensive cancer center. Multi-disciplinary management of ocular, orbital and adnexal cancers are highlighted using simple and tried-and-true algorithms. In addition, ocular problems caused as a direct result of cancer treatment are reviewed using illustrative photographs and case presentations. The content is provided by full-time ophthalmology faculty and fellows at M. D. Anderson Cancer Center. Experts in complementary disciplines such as ophthalmic pathology, dermatopathology, radiation oncology, radiology, and other surgical subspecialties have brought their unique perspective to each chapter. The book is abundant with clinical photographs as well as interesting case presentations that will help the clinician correctly diagnose cancers of the orbit, eye, and adnexal structures, initiate appropriate management, as well as recognize and treat common ocular complications of cancer therapy.
Cannabinoids
The present book is an outstanding summary of many aspects of cannabinoid research. It provides current knowledge about the pharmacology and therapeutic potential of cannabinoids as well as knowledge about the pharmacology, physiology, and pathology of the endogenous cannabinoid systems. The chapters are written by scientists who have made or are still making major contributions to the field. This book may well help generate novel ideas on how to approach the study of emotions.
