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Programmed cell death (PCD) plays pivotal roles in tumor progression, cancer therapeutics and resistance of tumor cells to therapy. This book examines the mechanisms involved in mediating and regulating PCD in cancer. It also provides a detailed indication of the utility of PCD in cancer therapy. The book features chapters on the current and future of RNA interference in therapeutics and Pathways involved in Stem Cell Survival and Death.
OSCEs for Intensive Care Medicine is an essential revision resource for doctors preparing to take the FFCIM or the EDIC. With over 100 questions divided into 8 OSCEs, this book covers the key areas of data, professionalism, resuscitation, and equipment, with further reading and hints and tips for high-quality self-assessment.
The traditional approaches to treat various cancers include chemotherapy, radiation and/or hormonal therapy. While these therapies continue to be effective in large part, they are not selective and highly toxic. There have been encouraging results in alternative therapeutic approach called antibody-mediated anti-cancer therapy, which is less toxic, more selective, and can also reverse drug/radiation resistance. Monoclonal antibodies or mAbs can be used to destroy malignant tumor cells and prevent tumor growth by blocking specific cell receptors. mAbs can bind only to cancer cell-specific antigens and induce an immunological response against the target cancer cell. The book covers the common and unique features of mAbs agains various cancer, gives the latest developments on the molecular, biochemical and genetic mechanisms of resistance by various mAbs, as well as discuss novel mAbs to overcome resistance.
Melanoma is an increasingly important public health problem. Although the cause of most malignant melanomas – over-exposure to ultraviolet light – is well known, effective treatment has remained challenging. The past several years have been marked by extraordinary developments in melanoma treatment in the arena of targeted therapeutics. This book describes these ground-breaking discoveries and their implications for clinical use. As melanoma biology is increasingly understood, so the development of targeted therapies for this disease is spurred ahead. This book covers both established signal transduction inhibitors and the fascinating emerging realm of molecularly-guided immunotherapies. This benchmark book provides the most up-to-date information on the new breed of melanoma therapies. Composed of the works of major researchers and clinicians, this book offers new insights, novel approaches, and promising data for effective treatment planning. Illuminating the latest advances in the field, it is a solid resource for clinical oncologists, translational scientists, and basic cancer researchers.
The South Shore is an intriguing mix of antiquity and modernity. The region's first settlement, Plymouth, is a top tourist destination, as more than one million visitors flock to it annually. Quincy showcases the region's Revolutionary War past, but even more of its fascinating sites are hidden behind an urban fa�ade. Along windswept beaches and cranberry bogs, the varied terrain is unique and captivating. From the birthplace of Abigail Adams in Weymouth to the historical houses of Hingham and the Old Scituate Light, author Zachary Lamothe uncovers the stories behind some of the most notable people and landmarks in New England.
1st-72nd include the annual report of the Secretary of the Board.