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Computational Systems Biology
This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as systems biology advances to provide clinical solutions to complex medical problems. In particular the work focuses on the engineering of biological systems and network modeling. - Logical information flow aids understanding of basic building blocks of life through disease phenotypes - Evolved principles gives insight into underlying organizational principles of biological organizations, and systems processes, governing functions such as adaptation or response patterns - Coverage of technical tools and systems helps researchers to understand and resolve specific systems biology problems using advanced computation - Multi-scale modeling on disparate scales aids researchers understanding of dependencies and constraints of spatio-temporal relationships fundamental to biological organization and function.
Computational Systems Biology
The best understanding of complex biological systems ultimately comes from details of the underlying atomic structures within it. In the absence of known structures of all protein complexes and interactions in a system, structural bioinformatics or modeling fill an important niche in providing predicted mechanistic information which can guide experiments, aid the interpretation of high-throughput datasets and help provide key details to model biological systems. This introductory review discusses the current state of this field and suggests how current datasets in systems studies can profit from a better integration of predicted or known structural information.
Reborn Princess With Super Power
In her previous life, she had died at the wedding of her long-loved boyfriend and her father's stepdaughter. Such hatred had allowed her to be reborn. With her memories and abilities from her past life, she would slowly regain what was hers. It's not that the time is not right...
Out of China's Earth
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Mutant p53 and MDM2 in Cancer
This book provides the readers with an overview of research on p53, which has been shown to play a role in numerous crucial biological pathways in normal and cancer cells. Leading scientist in the field, who have all made direct contributions to the understanding of the molecular events underpinning p53 function, have been invited to contribute the various chapters, which discuss the current knowledge of the signaling cascades that are activated by mutations in p53 and overexpression of MDM2, frequently found in human cancer and are major causes of oncogenesis. This book features chapters on the molecular basis of oncogenesis induced by gain of function mutation of p53, signaling pathways induced by MDM2 overexpression, control of mutant or wild-type p53 function by MDM2 and MDMX, p53 mutation in hereditary cancer and structural aspects that activate mutant p53 which can be targeted by drug therapy. This book should be useful for scientists at all levels.
