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Intrinsically Disordered Proteins
In this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). Beginning with an introduction to the concept of protein intrinsic disorder, Uversky then goes on to describe the peculiar amino acid sequences of IDPs, their structural heterogeneity, typical functions and disorder-based binding modes. In the final sections, Uversky discusses IDPs in human diseases and as potential drug targets. This volume provides a snapshot to researchers entering the field as well as providing a current overview for more experienced scientists in related areas.
Exploring Medical Biotechnology- in vivo, in vitro, in silico
This book on medical biotechnology offers a wide array of topics and cutting-edge research in the field featuring contributions from multiple authors, each specializing in their respective areas, making it highly valuable to science students and enthusiasts. The book provides comprehensive coverage on a diverse range of topics including sequence analysis, network pharmacology, drug discovery, CRISPR-Cas technology, precision medicine, neuroimaging biomarkers, therapeutics for neurodegenerative diseases, molecular pathogenesis of various diseases, plant-derived antioxidants, genetic approaches for disease diagnosis, cancer progression, immunotherapy, cancer biomarker identification, RNA Inter...
Biomolecular Forms and Functions
Understanding the functions and properties of molecules in living systems requires a detailed knowledge of their three-dimensional structures and the conformational variability that allows them to adopt multiple functional forms. Interpreting biological systems in the language of three-dimensional structures is of fundamental importance and innumerable research groups around the world are working in this area. This book is a compilation of articles describing attempts at understanding the intricacies of biological systems through the structures of and interactions between their constituent molecules.
Biomolecular Forms And Functions: A Celebration Of 50 Years Of The Ramachandran Map
Understanding the functions and properties of molecules in living systems requires a detailed knowledge of their three-dimensional structures and the conformational variability that allows them to adopt multiple functional forms. Interpreting biological systems in the language of three-dimensional structures is of fundamental importance and innumerable research groups around the world are working in this area. This book is a compilation of articles describing attempts at understanding the intricacies of biological systems through the structures of and interactions between their constituent molecules.
Reframing the Diplomat
In Reframing the Diplomat Albertine Bloemendal offers a unique window onto the unofficial dimension of Cold War transatlantic relations by analyzing the diplomatic role of the Dutch Atlanticist Ernst van der Beugel as a government official and as a private diplomat. After a career with the Dutch government at the frontlines of the Marshall Plan, European integration and transatlantic relations, Van der Beugel pursued a more freestyle approach to diplomacy as a private citizen, most notably through his role as Secretary-General of the illustrious Bilderberg Meetings and his ties to the European and American foreign policy establishments. This book also traces his close friendship with Henry Kissinger, which provided him with a direct line to the White House.
On protein structure, function and modularity from an evolutionary perspective
We are compounded entities, given life by a complex molecular machinery. When studying these molecules we have to make sense of a diverse set of dynamical nanostructures with wast and intricate patterns of interactions. Protein polymers is one of the major groups of building blocks of such nanostructures which fold up into more or less distinct three dimensional structures. Due to their shape, dynamics and chemical properties proteins are able to perform a plethora of specific functions essential to all known cellular lifeforms. The connection between protein sequence, translated into protein structure and in the continuation into protein function is well accepted but poorly understood. Malf...
Strategic Environmental Assessment
Strategic Environmental Assessment (SEA) is a new approach to environmental assessment, global in scope, which considers the environmental impacts of policies, plans and programmes. It is already in use in a number of countries and is rapidly being adopted by those involved with environmental management and regulation, including governments, official and voluntary sector agencies, academic courses and consultancies. This text defines and analyzes SEA within the overall context of environmental assessment. It introduces and reviews the current state of SEA, evaluates its application in a number of countries with a range of detailed case studies, provides a critique of its techniques and an analysis of its importance for the future.
Current Catalog
First multi-year cumulation covers six years: 1965-70.
