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Genealogy of the Lewis Family in America
Chiefly a record of some of the descendants of John Lewis. He was born in Donegal County, Ireland 1678 to Andrew Lewis and Mary Calhoun. He married Margaret Lynn. He died in Virginia 1 Feb 1762. They were the parents of seven children.
The Holy Assassin
When Pope John Paul I dies in mysterious circumstances, his successor emerges from the conclave - unaware that he is in mortal danger. It is only the actions of a few loyal operatives that his death is prevented. 30 years later, Sarah Monteiro begins to uncover a covert agency, who's web of lies hide the true power behind the throne.
The Minute Man
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All Things Possible
Bobbie Sanders and her family live what some might call an idyllic life in Newport Beach, California. Happily married with two fairly normal teenagers, Bobbie confronts life's challenges with faith, humor, and humility. But life as Bobbie has come to know it is in flux. Her "kill them with kindness" attitude hits a wall when the irascible Mr. Ragoni moves in next door and rebuffs all her efforts to win him over. It's just the first sign of the seismic changes that threaten Bobbie's sense of security. Her husband, Bud, is going through a midlife crisis; her daughter, Pamela, is leaving convention and a fiancé behind for new horizons in Japan; and her sixteen-year-old son, Cole, shocks them all by befriending Mr. Ragoni ... to potentially disastrous effect. In All Things Possible, Bobbie's goodness--and her faith--are challenged to the core when real tragedy occurs, and she is forced to question the divine promise that God will not give her more than she can handle.
The SAR Magazine
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The Role of the Src-like Adaptor Protein in the Regulation of GM-CSFR Signaling
GM-CSF is a cytokine that regulates proliferation and survival of myeloid progenitor cells and stimulates dendritic cell (DC) differentiation. The Src-like adaptor protein (SLAP) has been implicated in the negative regulation of the GM-CSF receptor and downstream signaling in DC, although the mechanism of SLAP action remains unknown. We hypothesized that SLAP regulates GM-CSFR by recruiting CBL to the receptor, where it can ubiquitylate and target it for degradation. In this investigation we found that SLAP interacts with both SHP2 and CBL in a GM-CSF dependent manner and that SLAP and CBL over-expression alters GM-CSFR trafficking. SLAP is also important in regulating GM-CSF-stimulated DC development. In this study we determined that the role of SLAP in regulation of GM-CSF signaling is specific to differentiation in DC and we identified differentially expressed genes in Slap knock-out DC that may be important for maturation.
