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Cellular and Molecular Pathology of the Liver is extensive, complex and ranges from the understanding the basic molecular mechanisms that dictate everything from liver homeostasis to liver disease. Molecular Pathology of the liver is complicated due to some of the important functions inherent and unique to the Liver, including its innate ability to regenerate and the multitude of functions it plays for the wellbeing of an organism. With all this in mind, Molecular Pathology of Liver Diseases is organized in different sections, which will coherently and cohesively present the molecular basis of hepatic physiology and pathology. The first two sections are key to understanding the liver anatomy...
Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries ...
The brain vasculature nurtures and regulates basic functions of the central nervous system (CNS), acting as a barrier against pathogens. This book provides in-depth and focused data on the characteristics, function and role of brain blood vessels in health and disease. It addresses topics such as vascular activity, cell-cell communication, and the role of the endothelium in the development of the most prevalent types of cerebrovascular disease, neurodegenerative disorders, cognitive impairment, and vascular abnormalities. It offers an updated view of the current state of microvascular biology and research, and thus supports the discovery of new therapeutic agents and procedures directed at several CNS disorders.
Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and discuss the preclinical development of inhibitors specifically directed to upstream and downstream components of the pathway.
Signaling Pathways in Liver Diseases, 2nd edition focuses on signaling pathways which are particularly important in liver diseases. Recent progress brought hepatology to new frontiers. The increasing frequency of surgery on steatotic and cirrhotic liver obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations and how they can be influenced. Better comprehension of the cellular mechanisms participating in liver regeneration, hepato-cellular apoptosis and ischemia/reperfusion inquiry is mirrored by a dramatic increase in complexity. The number and scope of publications is intimidating and difficult for busy individuals to extract a coherent framework. This book will serve as a source of information facilitating the reading of the literature and the planning of trials. Translational medicine implies knowledge of the molecular targets for novel therapeutic strategies. It will furthermore stimulate more research and lead to better exchange between the laboratory, the clinical ward and the operation room.
Recent advances have carried hepatology to new frontiers. The increasing frequency with which steatotic and cirrhotic livers undergo surgery obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations. Comprehension of the signaling pathways participating in liver regeneration, hepatocellular apoptosis and ischemia/reperfusion injury is essential. This book serves as a source of information to facilitate the reading of the literature and the planning of trials. Translational medicine implies knowledge of the molecular targets of novel therapeutic strategies. It is our goal to stimulate more research that can lead to more exchanges between the laboratory, the clinical ward and the operating room.
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As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine. The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell bi...
Essential Concepts in Molecular Pathology, Second Edition, offers an introduction to molecular genetics and the "molecular" aspects of human disease. The book illustrates how pathologists harness their understanding of these entities to develop new diagnostics and treatments for various human diseases. This new edition offers pathology, genetics residents, and molecular pathology fellows an advanced understanding of the molecular mechanisms of disease that goes beyond what they learned in medical and graduate school. By bridging molecular concepts of pathogenesis to the clinical expression of disease in cell, tissue and organ, this fully updated, introductory reference provides the backgroun...
The Fourth Edition of the compendium pools together the knowledge and experience of experts from all over the world, who are engaged in teaching and research in the field of biochemistry, medical sciences and allied disciplines. Comprising 20 sections, the present edition of the book has been substantially revised incorporating the latest research and achievements in the field. Beginning appropriately with chemical architecture of the living systems, role and significance of biochemical reactions, organization of specialised tissues, and importance of food and nutrition, the book explores beyond traditional boundaries of biochemistry. The knowledge of various organ systems has been expanded ...