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Glycogen synthase kinase 3β: the nexus of chemoresistance, invasive capacity, and cancer stemness in pancreatic cancer
The treatment of pancreatic cancer remains a significant clinical challenge due to the limited number of patients eligible for curative (R0) surgery, failures in the clinical development of targeted and immune therapies, and the pervasive acquisition of chemotherapeutic resistance. Refractory pancreatic cancer is typified by high invasiveness and resistance to therapy, with both attributes related to tumor cell stemness. These malignant characteristics mutually enhance each other, leading to rapid cancer progression. Over the past two decades, numerous studies have produced evidence of the pivotal role of glycogen synthase kinase (GSK)3β in the progression of over 25 different cancer types,...
Earthquake Engineering
The official proceedings of the 10th world conference on earthquake engineering in Madrid. Coverage includes damage in recent earthquakes, seismic risk and hazard, site effects, structural analysis and design, seismic codes and standards, urban planning, and expert system application.
Integrated Studies of Social and Natural Environmental Transition in Laos
This book examines social and natural environmental changes in present-day Laos and presents a new research framework for environmental studies from an interdisciplinary point of view. In Laos, after the Lao version of perestroika, Chintanakaan Mai, in 1986, for better or worse, rural development and urbanization have progressed, and people’s livelihoods are about to change significantly. Compared to those of the neighboring countries of mainland Southeast Asia, however, many traditional livelihoods such as region-specific/ethnic-specific livelihood complexes, which combined traditional rice farming with a variety of subsistence activities, have been carried over into the present in Laos. ...
