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New High Throughput Technologies for DNA Sequencing and Genomics
Since the independent invention of DNA sequencing by Sanger and by Gilbert 30 years ago, it has grown from a small scale technique capable of reading several kilobase-pair of sequence per day into today's multibillion dollar industry. This growth has spurred the development of new sequencing technologies that do not involve either electrophoresis or Sanger sequencing chemistries. Sequencing by Synthesis (SBS) involves multiple parallel micro-sequencing addition events occurring on a surface, where data from each round is detected by imaging. New High Throughput Technologies for DNA Sequencing and Genomics is the second volume in the Perspectives in Bioanalysis series, which looks at the elec...
Next Generation Sequencing Technologies and Challenges in Sequence Assembly
The introduction of Next Generation Sequencing (NGS) technologies resulted in a major transformation in the way scientists extract genetic information from biological systems, revealing limitless insight about the genome, transcriptome and epigenome of any species. However, with NGS, came its own challenges that require continuous development in the sequencing technologies and bioinformatics analysis of the resultant raw data and assembly of the full length genome and transcriptome. Such developments lead to outstanding improvements of the performance and coverage of sequencing and improved quality for the assembled sequences, nevertheless, challenges such as sequencing errors, expensive processing and memory usage for assembly and sequencer specific errors remains major challenges in the field. This book aims to provide brief overviews the NGS field with special focus on the challenges facing the NGS field, including information on different experimental platforms, assembly algorithms and software tools, assembly error correction approaches and the correlated challenges.
Developments in Human Pluripotent Stem Cell Genome Engineering and in Situ Sequencing Technologies
Technology is a key driving force in the advancement of scientific discoveries. While DNA sequencing uncovered the blueprint of life encoded in the human genome, functional roles of sequence variants remain largely unknown. This thesis focuses on developing enabling technologies with broad applications for the study of genetic variations and gene regulation.
Next Generation Sequencing Technologies in Medical Genetics
This book introduces readers to Next Generation Sequencing applications in medical genetics. The authors discuss the direct application of next-generation sequencing to medicine, specifically, laboratory medicine or molecular diagnostics. The first part of the book contains chapters on sanger sequencing, NGS technologies, targeted-amplification and capture, and exome sequencing. The second part of the book focuses on genetic disorders diagnoses by NGS, prenatal diagnosis, muscular dystrophies, mitochondrial disorders diagnosis, and challenges in molecular diagnosis. Recent developments and potential future trends in NGS sequencing applications are highlighted, as well.
Development of the Technology for Changing the Sequence of Access to Shared Resources of Business Processes for Process Management Support
The model of the event log of the information system has been improved. The model contains the sequences of events consistent with implemented sequences of management actions within both the process approach and functional management approach. A strict linear order in time was assigned for each pair of events belonging to the same process. The model is designed to describe the prototype of the as-is business process.A case-based model of a business process, describing the features of its known implementations, reflected in the event log, has been proposed. The model combines a set of implemented sequences of operations of each process and takes into consideration the time to implement these ...
Mapping and Sequencing the Human Genome
There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.
Phones from Then to Now
America on the wire -- Reaching out -- Long wires and no wires -- Going mobile.
Wireless Technology from Then to Now
It is said that necessity is the mother of invention. But time is the driver of technological development. See how the inventions we use every day, from cars to cell phones, have evolved from their birth to today's technological advancements. A running timeline on each page makes this series perfect for supporting STEM topics in the elementary grades. Elementary readers will follow the sequence of how wireless technologies have brought us from the first Morse code radio transmission to today's "Internet of Things." Engaging photographs and a running timeline illustrate important inventions that have changed the way we use radio waves, from Bluetooth connections to cell phones. A table of contents, glossary, further resources, and an index are included.
Getting New Technologies Together
No detailed description available for "Getting New Technologies Together".
