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Single Domain Antibodies
The development of the hybridoma technology created the possibility to obtain unlimited amounts of monoclonal antibodies (mAb) with high specificity and affinity for any target and to introduce mAbs in a wide range of applications; however, the bulky size of mAbs, costly production, and cumbersome engineering hampered regularly their streamlined development in some applications. In Single Domain Antibodies: Methods and Protocols, expert researchers examine single variable domain antibody fragments, referred to as VH, VL, VHH or VNAR. These fragments are the smallest intact antigen-binding fragments that can be produced recombinantly at low cost. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Antibody Engineering Volume 2
Antibodies are indispensable tools for research, diagnosis, and therapy. Recombinant approaches allow the modification and improvement of nearly all antibody properties, such as affinity, valency, specificity, stability, serum half-life, effector functions, and immunogenicity. "Antibody Engineering" provides a comprehensive toolbox covering the well-established basics but also many exciting new techniques. The protocols reflect the latest "hands on" knowledge of key laboratories in this still fast-moving field. Newcomers will benefit from the proven step-by-step protocols, which include helpful practical advice; experienced antibody engineers will appreciate the new ideas and approaches. The book is an invaluable resource for all those engaged in antibody research and development.
Single-Domain Antibodies: Biology, Engineering and Emerging Applications
Single-domain antibodies (sdAbs) represent the minimal antigen binding-competent form of the immunoglobulin domain and have unique properties and applications. SdAbs are naturally produced as the variable domains of the heavy chain-only antibodies of camelid ruminants and cartilaginous fishes, but can also be engineered synthetically from autonomous human or mouse VH or VL domains. The scope of this research topic and associated e-book covers current understanding and new developments in (i) the biology, immunology and immunogenetics of sdAbs in camelids and cartilaginous fishes, (ii) strategies for sdAb discovery, (iii) protein engineering approaches to increase the solubility, stability and antigen-binding affinity of sdAbs and (iv) specialized applications of sdAbs in areas such diagnostics, imaging and therapeutics.
Handbook of Vertebrate Immunology
This unique book provides a comprehensive and comparative guide to the immune systems of major vertebrate species, including domestic and wild animals of veterinary or medical interest, fish and amphibia. Data in this essential reference work has been compiled by world-renowned editors and an international group of authors. For each species, the information is presented in a structured 'user-friendly' format allowing easy cross reference and comparison between the various species.This book will be considered the definitive reference work on vertebrate immunology and will be essential for scientists and professionals working in Immunology, Vaccinology or with Animal Models, for students of Ve...
Recombinant Antibodies for Immunotherapy
This book provides a comprehensive overview of the field of monoclonal antibodies through twenty-five articles by recognized experts in the field.
The "Nonsense" Papers
In the first volume of his "Nonsense" Papers series, James W. Astrada explored the controversial discussion of extraterrestrial influence on the human species and planet Earth. Now, on the precipice of the Digital Age, humanity is evolving at an astonishing rate-but are we evolving quickly enough to be entrusted with our advances? As we face the estimate that the human population may swell to ten billion by 2050, we must demand debate on how this finite planet can handle humanity's uncontrolled growth. This second installment of Astrada's series continues to focus on humanity's perilous journey to connect with the power cosmic and abandon our primitive and ignorant beliefs of the paranormal and the mystic. It also looks at the origins of humanity, Darwinism, geo-engineering, the dangers inherent as humans try to "control" the weather, and more. The race is on for the individual to ascend this reality we live in, to finally reconnect with the galactic families of sentient beings that await us if we try to master our humanity and all of its obstacles. Are we the greatest threat to our own existence? Are we ready for contact from another world?
Advances in Immunology
Advances in Immunology, a long established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research. - Now available online! - Highly respected review series with an impact factor in 2003 of of 7.424 and ranked number 8/114 - New Editor, Frederick Alt
The Birds, the Bees and the Platypuses
Michael Gross has been writing about science full time for the last eight years and as a night time hobby for the previous seven. From his treasure troves, he now presents his favourite science stories from these 15 years. What are the attractions that make him revisit a topic or reread an article again and again? Often, it's the sheer craziness of wildly unexpected findings or grotesquely oversized challenges. In other stories, there is a sexy element or an unexpected insight into the human condition. And sometimes, when reporting new and future technologies, the author just can't help thinking: >cooooooool!
