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Single Domain Antibodies
The development of the hybridoma technology created the possibility to obtain unlimited amounts of monoclonal antibodies (mAb) with high specificity and affinity for any target and to introduce mAbs in a wide range of applications; however, the bulky size of mAbs, costly production, and cumbersome engineering hampered regularly their streamlined development in some applications. In Single Domain Antibodies: Methods and Protocols, expert researchers examine single variable domain antibody fragments, referred to as VH, VL, VHH or VNAR. These fragments are the smallest intact antigen-binding fragments that can be produced recombinantly at low cost. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Current Trends in Monoclonal Antibody Development and Manufacturing
Monoclonal antibodies represent one of the fastest growing areas of new drug development within the pharmaceutical industry. Several blockbuster products have been approved over the past several years including Rituxan, Remicade, Avastin, Humira, and Herceptin. In addition, over 300 new drugs are currently in clinical trials. With both large, established biotechnology companies and small start-ups involved in the development of this important class of molecules, monoclonal antibodies products will become increasingly prevalent over the next decade. Recently the regulatory review of monoclonal antibodies has been moved from Center for Biologics and Research to the Center for Drug Evaluation a...
Antibody Engineering Volume 2
Antibodies are indispensable tools for research, diagnosis, and therapy. Recombinant approaches allow the modification and improvement of nearly all antibody properties, such as affinity, valency, specificity, stability, serum half-life, effector functions, and immunogenicity. "Antibody Engineering" provides a comprehensive toolbox covering the well-established basics but also many exciting new techniques. The protocols reflect the latest "hands on" knowledge of key laboratories in this still fast-moving field. Newcomers will benefit from the proven step-by-step protocols, which include helpful practical advice; experienced antibody engineers will appreciate the new ideas and approaches. The book is an invaluable resource for all those engaged in antibody research and development.
Recombinant Antibodies for Immunotherapy
This book provides a comprehensive overview of the field of monoclonal antibodies through twenty-five articles by recognized experts in the field.
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine
Here is a broad overview of the central topics and issues in molecular biology and molecular medicine, with up-to-the minute information about developments in the field including pharmacogenics and pharmacoproteomics, gene therapy and gene regulation. Presented in an accessible A to Z format, the Encyclopedia’s more than 2000 entries are written by leading experts in genomics and proteomics. The entries comprise in-depth essays, illustrated with full-color figures, and presented in a lucid style that will appeal to both experts and interested lay people.
Protectors of Pluralism
Sheds new light on the relationship between tolerance and religion, concluding that local religious minorities are most likely to protect pluralism.
Belgium in the Second World War
When the Nazis invaded neutral Belgium in May 1940, defeat and occupation were inevitable but Belgian armed forces held out against a vastly superior enemy for 18 days. The elected Government went into exile in London but King Leopold III controversially remained with his people as a prisoner.??As described in this authoritative book, Belgians continued the fight both outside and inside their country. There were eventually two complete Belgian RAF squadrons. The Colonial Army defeated the Italians in East Africa and the Belgian Brigade fought from Normandy to Germany.??The Belgian Resistance organized escape routes, sabotaged their occupiers' activities and spied for the Allies. 17,000 died or were executed and a further 27,000 survived detention. Meanwhile others collaborated and fought for the Nazis and large numbers were tried post-war for war crimes and treason.??About half the Jews in Belgium in 1940 died in the Holocaust and there are many stirring stories of courage, as well as tragic ones.??This is an overdue and honest account of one Nation's very varied experiences during five years of Nazi occupation and oppression.
Single Domain Antibodies
The development of the hybridoma technology created the possibility to obtain unlimited amounts of monoclonal antibodies (mAb) with high specificity and affinity for any target and to introduce mAbs in a wide range of applications; however, the bulky size of mAbs, costly production, and cumbersome engineering hampered regularly their streamlined development in some applications. In Single Domain Antibodies: Methods and Protocols, expert researchers examine single variable domain antibody fragments, referred to as VH, VL, VHH or VNAR. These fragments are the smallest intact antigen-binding fragments that can be produced recombinantly at low cost. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Stad in verzet
Antwerpen was de belangrijkste verzetsstad in Vlaanderen tijdens de Tweede Wereldoorlog. Wat weten we vandaag de dag - 80 jaar na de bevrijding van België - over die geschiedenis? Hoe verzetten de Antwerpenaren zich tegen de nazibezetter? En wat vertelt het Antwerpse verhaal over de bredere verzetsgeschiedenis van ons land? In Stad in verzet gaan acht historici op zoek naar antwoorden: Nico Wouters, Frank Seberechts, Jan Laplasse, Michèle Corthals, Babette Weyns, Janiv Stamberger, Dorien Styven en Herman Van Goethem. Het voorwoord is van Bart De Wever.
