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High Field Parahydrogen Induced Polarization of Succinate and Phospholactate
Abstract: The signal enhancement provided by the hyperpolarization of nuclear spins of metabolites is a promising technique for diagnostic magnetic resonance imaging (MRI). To date, most 13C-contrast agents are hyperpolarized utilizing a complex or cost-intensive polarizer. Recently, the in situ parahydrogen-induced 13C hyperpolarization was demonstrated. Hydrogenation, spin order transfer (SOT) by a pulsed NMR sequence, in vivo administration, and detection was achieved within the magnet bore of a 7 Tesla MRI system. So far, the hyperpolarization of the xenobiotic molecule 1-13C-hydroxyethylpropionate (HEP) and the biomolecule 1-13C-succinate (SUC) through the PH-INEPT+ sequence and a SOT s...
Metabolic Tumor Imaging with Rapidly Signal-enhanced 1-13C-pyruvate-d3
Abstract: The metabolism of malignant cells differs significantly from that of healthy cells and thus, it is possible to perform metabolic imaging to reveal not only the exact location of a tumor, but also intratumoral areas of high metabolic activity. Herein, we demonstrate the feasibility of metabolic tumor imaging using signal-enhanced 1-13C-pyruvate-d3, which is rapidly enhanced via para-hydrogen, and thus, the signal is amplified by several orders of magnitudes in less than a minute. Using as a model, human melanoma xenografts injected with signal-enhanced 1-13C-pyruvate-d3, we show that the conversion of pyruvate into lactate can be monitored along with its kinetics, which could pave the way for rapidly detecting and monitoring changes in tumor metabolism
Materials
Presents a fully interdisciplinary approach with a stronger emphasis on polymers and composites than traditional materials books Materials science and engineering is an interdisciplinary field involving the properties of matter and its applications to various areas of science and engineering. Polymer materials are often mixed with inorganic materials to enhance their mechanical, electrical, thermal, and physical properties. Materials: Introduction and Applications addresses a gap in the existing textbooks on materials science. This book focuses on three Units. The first, Foundations, includes basic materials topics from Intermolecular Forces and Thermodynamics and Phase Diagrams to Crystalli...
The Adventures of Menahem-Mendl
Letters between a husband and wife provide another magical glimpse into the world of Sholom Aleichem.
Minerals as Advanced Materials II
This book is a collection of papers that are devoted to various aspects of interactions between mineralogy and material sciences. It will include reviews, perspective papers and original research papers on mineral nanostructures, biomineralization, micro- and nanoporous mineral phases as functional materials, physical and optical properties of minerals, etc. Many important materials that dominate modern technological development were known to mineralogists for hundreds of years, though their properties were not fully recognized. Mineralogy, on the other hand, needs new impacts for the further development in the line of modern scientific achievements such as bio- and nanotechnologies as well as by the understanding of a deep role that information plays in the formation of natural structures and definition of natural processes. It is the idea of this series of books to provide an arena for interdisciplinary discussion on minerals as advanced materials.
Guide for Local Authorities on Developing Sustainable Tourism
Also available, supplementary vol. on Sub-Saharan Africa (1999) (ISBN 9284403111), and supplementary vol. on Asia and the Pacific (1999) (ISBN 928440326X). Supersedes "Sustainable tourism development: a guide for local planners" (1993) (ISBN 9284400384)
Polysaccharides II
This book has the Highest Impact Factor of all publications ranked by ISI within Polymer Science. It contains short and concise reports on physics and chemistry of polymers, each written by the world renowned experts. The book is still valid and useful after 5 or 10 years. The electronic version is available free of charge for standing order customers at: springer.com/series/12/
Europe and the Black Sea Region
When the scientific study of the Black Sea Region began in the late 18th and early 19th centuries, initially commissioned by adjacent powers such as the Habsburg and the Russian empires, this terra incognita was not yet considered part of Europe. The eighteen chapters of this volume show a broad range of thematic foci and theoretical approaches - the result of the enormous richness of the European macrocosm and the BSR. The microcosms of the many different case studies under scrutiny, however, demonstrate the historical dimension of exchange between the allegedly opposite poles of `East' and `West' and underscore the importance of mutual influences in the development of Europe and the BSR.
