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Definition of a High-confidence Mitochondrial Proteome at Quantitative Scale
Abstract: Mitochondria perform central functions in cellular bioenergetics, metabolism, and signaling, and their dysfunction has been linked to numerous diseases. The available studies cover only part of the mitochondrial proteome, and a separation of core mitochondrial proteins from associated fractions has not been achieved. We developed an integrative experimental approach to define the proteome of yeast mitochondria. We classified > 3,300 proteins of mitochondria and mitochondria-associated fractions and defined 901 high-confidence mitochondrial proteins, expanding the set of mitochondrial proteins by 82. Our analysis includes protein abundance under fermentable and nonfermentable growth...
Functions and Mechanisms of Bacterial Protein Homeostasis and Stress Responses
The Cover Image for This Research Topic is Used With Permission of the Authors and Publishers of the Following Article: Winkler J, Seybert A, König L, Pruggnaller S, Haselmann U, Sourjik V, Weiss M, Frangakis AS, Mogk A, Bukau B.EMBO J. 2010 Mar 3;29(5):910-23. doi: 10.1038/emboj.2009.412. Epub 2010 Jan 21
Quantitative Methods in Proteomics
Protein modifications and changes made to them, as well as the quantities of expressed proteins, can define the various functional stages of the cell. Accordingly, perturbations can lead to various diseases and disorders. As a result, it has become paramount to be able to detect and monitor post-translational modifications and to measure the abundance of proteins within the cell with extreme sensitivity. While protein identification is an almost routine requirement nowadays, reliable techniques for quantifying unmodified proteins (including those that escape detection under standard conditions, such as protein isoforms and membrane proteins) is not routine. Quantitative Methods in Proteomics...
Erfolgsfaktoren der Beschaffung im Einzelhandel
Markus Janz identifiziert grundlegende Dimensionen der Beschaffungsführung und zeigt, in welchen Situationen die partnerschaftliche Ausgestaltung von Lieferantenbeziehungen sinnvoll ist. Er stellt eine Methode vor, die es ermöglicht, diesen aus einem kausalanalytischen Erfolgsfaktorenmodell ermittelten Zusammenhang in ein für die Praxis nutzbares Entscheidungsunterstützungsinstrument in Form eines Portfoliomodells zu überführen.
Beyond Territoriality
This book traces the evolution of transnational legal authority in the course of globalization. Representative case studies buttress its conclusion that today transnational authority is multifaceted, a phenomenon that renders unreliable the concepts of territoriality/extraterritoriality as global governance markers.
Daxlanden
None
Subcellular Proteomics
This volume summarizes the new developments that made subcellular proteomics a rapidly expanding area. It examines the different levels of subcellular organization and their specific methodologies. In addition, the book includes coverage of systems biology that deals with the integration of the data derived from these different levels to produce a synthetic description of the cell as a system.
