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Definition of a High-confidence Mitochondrial Proteome at Quantitative Scale
Abstract: Mitochondria perform central functions in cellular bioenergetics, metabolism, and signaling, and their dysfunction has been linked to numerous diseases. The available studies cover only part of the mitochondrial proteome, and a separation of core mitochondrial proteins from associated fractions has not been achieved. We developed an integrative experimental approach to define the proteome of yeast mitochondria. We classified > 3,300 proteins of mitochondria and mitochondria-associated fractions and defined 901 high-confidence mitochondrial proteins, expanding the set of mitochondrial proteins by 82. Our analysis includes protein abundance under fermentable and nonfermentable growth...
Oral Biofilms
Biofilms are highly organized polymicrobial communities that are embedded in an extracellular matrix and formed on natural and artificial surfaces. In the oral cavity, biofilms are formed not only on natural teeth, but also on restorative materials, prosthetic constructions, and dental implants. Oral diseases like caries, gingivitis, periodontitis, and also pulp inflammation are associated with biofilms. This publication is an up-to-date overview on oral biofilms from different clinically relevant perspectives. Experts comprising basic researchers and clinicians report on recent research relating to biofilms - from general summaries to recommendations for daily clinical work. This book cover...
Activity-Based Protein Profiling
This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions.
Quantum Proofs
Quantum Proofs provides an overview of many of the known results concerning quantum proofs, computational models based on this concept, and properties of the complexity classes they define. In particular, it discusses non-interactive proofs and the complexity class QMA, single-prover quantum interactive proof systems and the complexity class QIP, statistical zero-knowledge quantum interactive proof systems and the complexity class QSZK, and multiprover interactive proof systems and the complexity classes QMIP, QMIP*, and MIP*. Quantum Proofs is mainly intended for non-specialists having a basic background in complexity theory and quantum information. A typical reader may be a student or researcher in either area desiring to learn about the fundamentals of the (actively developing) theory of quantum interactive proofs.
Information Security and Privacy
This book constitutes the refereed proceedings of the 26th Australasian Conference on Information Security and Privacy, ACISP 2021, held in Perth, WA, Australia, in November 2021. The 35 full papers presented were carefully revised and selected from 157 submissions. The papers present and discuss all aspects of information security and privacy as well as machine learning for privacy and much more.
Neuroacanthocytosis Syndromes
Neuroacanthocytosis Syndromes is the first comprehensive review of a field that has not yet received the attention it deserves. Affecting the brain as well as the circulating red cells, these multi-system disorders in the past had often been mistaken for Huntington's disease. Recent breakthroughs have now identified the molecular basis of several of these. This volume grew out of the first international scientific meeting ever devoted to neuroacanthocytosis and provides in-depth information about the state of the art. Its thirty chapters were written by the leading authorities in the field to cover the clinical as well as the basic science perspective, including not only molecular genetics but also experimental pharmacology and cell membrane biology, among others. The book vehemently poses the question of how the membrane deformation of circulating red blood cells relates to degeneration of nerve cells in the brain, the basal ganglia, in particular. It provides a wealth of data that will help to solve an intriguing puzzle and ease the suffering of those affected by one of the neuroacanthocytosis syndromes.
Identity-based Cryptography
"What if your public key was not some random-looking bit string, but simply your name or email address? This idea, put forward by Adi Shamir back in 1984, still keeps cryptographers busy today. Some cryptographic primitives, like signatures, were easily adapted to this new "identity-based" setting, but for others, including encryption, it was not until recently that the first practical solutions were found. The advent of pairings to cryptography caused a boom in the current state-of-the-art is this active subfield from the mathematical background of pairing and the main cryptographic constructions to software and hardware implementation issues. This volume bundles fourteen contributed chapters written by experts in the field, and is suitable for a wide audience of scientists, grad students, and implementors alike." --Book Jacket.
