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Gene Profiles in Drug Design
With the successful mapping of the human genome, we have entered an age of unprecedented opportunity in which researchers are beginning to apply this vast repository of knowledge to the treatment of human disease. Gene-profiling technologies and the concept of individualized medicine are leading to the development of drugs with enhanced specificity
MIF Family Cytokines in Innate Immunity and Homeostasis
The role of the cytokine macrophage migration inhibitory factor (MIF) in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well-established. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, metabolism, and cellular stress responses. MIF’s molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. New family members, such as D-dopachrome tautomerase, or MIF-2, and the closely homologous genes encoding by parasites have been defined and are being functionally characterized. MIF directed therapies also are entering clinical testing and ultimately may be applied in a pharmacogenomics manner. This book provides a comprehensive synthesis of the state-of-the-art of MIF science. The intended audience are post-graduate students and researchers in inflammation, innate immunity, immunology, and immunopathology.
Understanding COVID-19: The Role of Computational Intelligence
This book provides a comprehensive description of the novel coronavirus infection, spread analysis, and related challenges for the effective combat and treatment. With a detailed discussion on the nature of transmission of COVID-19, few other important aspects such as disease symptoms, clinical application of radiomics, image analysis, antibody treatments, risk analysis, drug discovery, emotion and sentiment analysis, virus infection, and fatality prediction are highlighted. The main focus is laid on different issues and futuristic challenges of computational intelligence techniques in solving and identifying the solutions for COVID-19. The book drops radiance on the reasons for the growing profusion and complexity of data in this sector. Further, the book helps to focus on further research challenges and directions of COVID-19 for the practitioners as well as researchers.
Chemokines in Viral Infections
In the past five years, a large number of new chemokines and chemokine receptors have been identified. Alarming progress in the areas of bioinformatics and expressed sequence tag (EST) databases attributed to this development. Recent discoveries provide compelling evidences supporting the roles of these messengers and their receptors in the control of viral infection as well as in aiding virus survival. Chemokines in Viral Infections is the first to provide a comprehensive write up on the various evidences available to date on the interactions between host chemokine system and viral chemokines. This book intends to unravel the chemokine constellation in the context of viral infections, a versatility that was not fully understood five years ago. This book is excellent reading material and will be of interest to research scientists, clinicians and postgraduate students.
Biology of Emerging Viruses
This volume reports on a meeting, co-sponsored by the American Society for Microbiology and the Vietnam Association for Microbiology, which provided a common platform for Vietnamese scientists and ASM international members to discuss emerging viral infectious diseases with special emphasis on the Asia-Pacific region. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.
Idiopathic Inflammatory Myopathies
The term "myositis" covers a variety of disorders often designated "idiopathic inflammatory myopathies". Although they are rather rare compared to other rheumatic diseases, they often cause severe disability and not infrequently increased mortality. The additional involvement of important internal organs such as the heart and lungs, is not uncommon. Thus, there is a great need for a better understanding of the etiopathogenesis of myositis, which may lead to improved treatment and care for these patients. Major advances regarding research and medical treatment have been made during recent years. Of particular importance is the discovery of the Myositis specific autoantibodies, linking immunological and pathological profiles to distinct clinical disease entities. A wide range of aspects of myopathies is covered in the book presented by highly qualified authors, all internationally known for their expertice on inflammatory muscle diseases. The book covers diagnostic, pathological, immunological and therapeutic aspects of myositis.
ORAL CANCER
This book serves as a guide in medical astrology not just for the astrologers and astrology enthusiasts, but also for those who have no previous knowledge of astrology. This book is the first of its kind in detecting oral cancer in the horoscope. It also offers techniques of predicting different types of cancer, diseases of the mouth and the face including various kinds of eye problems, speech disorders, cleft palate and five types of non-cancerous and pre-cancerous lesions in the mouth. A section on palm lines related to prediction of diseases is added. More importantly the book offers simple astrological remedial measures, the scientific rationale behind them and the methods to derive remedies from the horoscope. For print copy, write to jayasreebooks@gmail.com
Emerging Viral Diseases of Southeast Asia
Experts discuss the threat posed by emerging viruses and describe ongoing efforts to face future outbreaks by searching for new antivirals, developing new vaccines, and improving methods of diagnosis and surveillance. Australian contributor.
Alphaviruses
Alphaviruses comprise a fascinating group of small, enveloped, single-stranded, positive-sense, RNA viruses. They are usually transmitted by arthropod vectors (usually mosquitoes). Of the thirty known species, eight are important human pathogens (e.g. Venezuelan equine encephalitis virus), while one, salmonid alphavirus, is of economic importance to the farmed fish industry. Due to their small size, alphaviruses have historically been utilized as model systems for the analysis of viral pathogenesis. Understanding alphavirus molecular biology, pathogenesis, and host interactions are key areas of research that have applications, not only in disease prevention, but also in permitting the exploi...
