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This volume is THE definitive, completely up-to-date, reference work for ALL researchers and clinicians working in autoimmunity.Up-to-Date: This is a timely critical review of more than 100 autoantibodies by leading experts in their respective fields, and includes many recent references.International Experts: The 120 Chapters have been written by the top international cadre of authors who have provided structured, expert contributions.Comprehensive: A total comprehensive perspective on the processes which induce, inhibit or otherwise affect autoantibodies in humans.Useful to Researchers and Clinicians: Chapters generally include methods of detection, pathogenic role, factors in pathogenicity and genetics as well as clinical utility with disease associations and frequencies.
The third volume in this prolific series of comprehensive reviews of topics of contemporary interest for specialists in B cell immunology. Antibodies have always been vital to any major progress within immunology. From diagnostic tools to vehicles for modern therapy against cancer, infections, and autoimmune diseases, antibodies serve many purposes yet our knowledge of them, their properties and structural characteristics is still incomplete. This collection of articles investigates the field of VDJ recombination, the Ku Autoantigen, diseases that impact on VDJ recombination, the evolution of antigen recognition molecules, the use of intravenous immunoglobulin in human immunotherapy, and rheumatoid factors produced in rheumatoid arthritis patients that may indicate a pathogenetic predisposition. Exciting, innovative technological developments used for exploring new areas of study and medical applications are also covered. Traditional aspects of the field are revisited so that relevant information and concepts are maintained as a point of reference to more modern aspects.
Intravenous Immunoglobulins: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Intravenous Immunoglobulins in a compact format. The editors have built Intravenous Immunoglobulins: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Intravenous Immunoglobulins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Intravenous Immunoglobulins: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Proceedings of the Second International Symposium held in Chapel Hill, North Carolina, November 3-5, 1993
Autoimmune Reactions tackles fundamental questions about how the immune system can destroy invading microbial pathogens without causing damage to itself and other "self" systems. The authoritative experts writing here explore the mechanistic aspects of such autoimmune diseases as lupus, rheumatoid arthritis, diabetes, and autoimmune thyroid disease, and where possible delineate how malfunctioning immunological mechanisms can lead to clinical symptoms. They also discusses possible general mechanisms of autoimmune disease-e.g., molecular mimicry and dysfunctional antigen presentation-and their current limitations as unifying explanations of the diseases described. The book illustrates the type of thinking and research that should eventually permit development of palliatives and cures for autoimmune diseases.
The consequences of diseases involving the immune system now appear to have much wider impact on health care and management. Even though over the last decade, our understanding of the basic immunological mechanisms underlying various diseases has increased considerably, the application of these research findings for drug development have not been fully exploited. With a view to analyzing the current strategies for immunotherapy, Immunopharmacology: Strategies for Immunotherapy brings together contributions from experts involved with various aspects of immunology. It explores new approaches for prevention and treatment of diseases, and these approaches invariably involve the manipulation of t...
We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.
Especially the past two decades have seen renewed interest in the vasculitides. In this volume an international expert group presents the current state of knowledge and concentrates on principles of immune modulating therapy. Drawing from their work in rheumatology, nephrology, internal medicine, connective tissue disease and clinical immunology, they present new concepts in classificiation, diagnosis and pathophysiology of the vasculitides. Evidence from experimental and clinical trials is reviewed, as well as the outlook for further research.
This is a high-level clinical reference text on new developments in therapeutic immunomodulation. It describes the mechanisms of action and clinical use of intravenous immunoglobulin (IVIg), including its effectiveness in clinical conditions. The book also contains three chapters on the safety of IVIg, an overview chapter on IVIg therapy today and tomorrow, and a selected bibliography compiled primarily for practicing physicians. The contributing authors are IVIg experts from the USA, UK, Europe, and Australia.