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Improving the Utility and Translation of Animal Models for Nervous System Disorders
Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in ...
Best Life
Best Life magazine empowers men to continually improve their physical, emotional and financial well-being to better enjoy the most rewarding years of their life.
Make Life Visible
This open access book describes marked advances in imaging technology that have enabled the visualization of phenomena in ways formerly believed to be completelyimpossible. These technologies have made major contributions to the elucidation of the pathology of diseases as well as to their diagnosis and therapy. The volume presents various studies from molecular imaging to clinical imaging. It also focuses on innovative, creative, advanced research that gives full play to imaging technology inthe broad sense, while exploring cross-disciplinary areas in which individual research fields interact and pursuing the development of new techniques where they fuse together. The book is separated into ...
Imaging in CNS Drug Discovery and Development
Drug development today needs to balance agility, speed, and risk in defining probability of success for molecules, mechanisms, and therapeutic concepts. New techniques such as fMRI promise to be part of a sequence that could transform drug development. Although numerous review articles exist that discuss the use of imaging in drug development, no one source is available that combines the various techniques and includes a discussion of disease mapping. Imaging in CNS Drug Discovery and Development, Implications for Disease and Therapy will serve to distill the most salient developments in the use of imaging in drug development and disease mapping. It will launch evolving concepts that integrate new imaging technologies and paradigms with molecular medicine and molecular profiling ("monics") as well as consider the ethical issues that arise as a result of disease or state diagnosis and the use of imaging in the public eye.
From Acute to Chronic Back Pain
Chronic back pain has been and continues to be a major cause of distress (both to people with persistent pain and their significant others), disability, work loss, and a huge cost to society. Moreover, with the aging population, it is becoming even more prevalent and as a consequence is having an escalating impact upon the healthcare systems and society as a whole worldwide. A significant issue concerns understanding why, although the majority of people with acute back symptoms recover in a reasonable time, a significant minority evolve into patients with chronic pain and prolonged pain-related disability. Understanding the variables that contribute to chronicity could serve as a basis for e...
Chronic Pain
Everyone has experienced pain at one point or another, but disorders such as fibromyalgia and multiple sclerosis cause severe, long-term pain that can greatly limit a person's everyday activities. Because the cause of this pain is not visible, many people do not fully understand these disorders. This volume dispels the myths surrounding chronic pain to give readers a better understanding of the daily struggles people who suffer from it face. Informative sidebars and detailed infographics help young adults learn how to support a loved one who is dealing with an invisible illness or cope with their own chronic pain diagnosis.
The New Mind Readers
Thinking on 20 watts -- The visible mind -- fMRI grows up -- Can fMRI read minds? -- How do brains change over time? -- Crimes and lies -- Decision neuroscience -- Is mental illness just a brain disease? -- The future of neuroimaging.
Translational Pain Research
One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practical
