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Continued Learning of Tissue-specific Immunity from the Immuno-Pathological Spectrum of Leprosy
Leprosy is one of the oldest recorded debilitating diseases affecting mankind, the immunopathology of which is characterized by fluctuating granulomatous inflammation that targets mainly skin and peripheral nerve. The disease is caused by infection with Mycobacterium leprae, a slow growing obligatory intracellular and non-cultivatable organism. The disease is manifested with diverse pathology due to varied immune (both innate and adaptive) responses of the hosts as a result of cognate interaction with the organism. Of note, leprosy can be regarded as a unique model to elucidate the complexity of host immunity at both skin and systemic levels.
New Insights in Leprosy (Hansen's Disease)
Leprosy (or Hansen’s disease) is a chronic infectious granulomatous disease caused by Mycobacterium leprae and Mycobacterium lepromatosis that affects predominantly the skin and peripheral nerves. Leprosy is one of the oldest known illnesses of mankind; however, it is still one of the most neglected diseases worldwide, impacting more than 120 countries, mainly in underdeveloped settings. Early diagnosis and treatment are crucial for reducing the burden of this disease and avoiding long-term irreversible consequences such as deformities and mutilations. Thus, the World Health Organization has focused its efforts on preventive programs as well as the search for easy-to-handle diagnosis tools and the implementation of new strategies to improve the therapeutic options available.
Anderson Guide to Enjoying Greenwich Connecticut
From how to join a country club to where to go rock climbing. From where to get a tent permit to where to get your rugs cleaned. This insiders guide to Greenwich Connecticut is intended for long time residents and newcomers alike. Over 160 restaurants are reviewed (including the severn best), 350 stores and over 170 sports and fitness activities are listed.
Insights in Infectious Agents and Disease: 2022
We are now entering the third decade of the 21st Century, and, especially in the last years, the achievements made by scientists in the field of Microbiology have been exceptional, leading to major advancements. Frontiers has organized a series of Research Topics to highlight the latest advancements in science in order to be at the forefront of science in different fields of research. This specific editorial initiative, led by Dr. Axel Cloeckaert is focused on new insights, novel developments, current challenges, latest discoveries, recent advances and future perspectives in the field. The Research Topic solicits brief, forward-looking contributions from the editorial board members that describe the state of the art, outlining recent developments and major achieved accomplishments, future challenges and how to address those challenges to move the field forward. Reviews, Mini-Reviews, Perspectives, and Opinions summarizing the current state and future directions of the field are particularly welcome in this collection.
Statement of Disbursements of the House
Covers receipts and expenditures of appropriations and other funds.
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