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Angiogenesis is the physiological process where new blood vessels grow from existing ones, in order to replenish tissues suffering from inadequate blood supply. Perhaps the most studied angiogenic process occurs in solid tumors whose growing mass and expanding cells create a constant demand for additional supply of oxygen and nutrients for survival. However, other physiological and clinical conditions, such as wound healing, ischemic events, autoimmune and age-related diseases also involve angiogenesis. Angiogenesis is a well-structured process that begins when oxygen and nutrients are depleted, leading to the release of chemokines and growth factors that attract immune cells, particularly m...
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thrombospondin-l may be encoded by a tumor suppressor gene. Dr. O'Reilly discusses angiostatin, an exciting recently discovered factor derived from the fibrinolytic proenzyme plasminogen that inhibits tumor angiogenesis, primary tumor growth, and formation of metastases. In addition to the soluble class of angiogenesis-regulatory factors discussed above, interactions of endothelial cells with components of the extracellular matrix and with other cell types are critical for proper formation of vessels. Drs. Grant and Kleinman discuss the role of laminin and other matrix molecules in regulation of capillary formation. Dr. van Hinsbergh and colleagues describe the role of fibrin and the fibrino...
Janis Kuby’s groundbreaking introduction to immunology was the first textbook for the course actually written to be a textbook. Like no other text, it combined an experimental emphasis with extensive pedagogical features to help students grasp basic concepts. Now in a thoroughly updated new edition, Kuby Immunology remains the only undergraduate introduction to immunology written by teachers of the course. In the Kuby tradition, authors Jenni Punt, Sharon Stranford, Patricia Jones, and Judy Owen present the most current topics in an experimental context, conveying the excitement of scientific discovery, and highlight important advances, but do so with the focus on the big picture of the st...
"These are the questions at the heart of the stories in The Wounded Leader. In these stories leaders struggle to make sense of their wounding experiences. We meet a principal who felt undermined by a contentious staff, another whose early mistakes ignited rumors and discontent, a leader who felt shunned when she took a position at a failing school, and a superintendent at odds with the school board."--Jacket.
Blends biology, clinical science, genetics, and molecular biology of the immune system to provide a complete account of our knowledge of immunology New features include full-color artwork and design, over 50 new figures, and text that has been completely revised to reflect the very latest references Incorporates a variety of pedagogical aids to assist students in the learning process, including chapter outlines, objectives, and summaries, as well as a self-evaluation section
This collection of ten essays on Banaras, one of the largest urban centers in India's eastern Gangetic plain, is united by a common interest in examining everyday activities in order to learn about shared values and motivations, processes of identity formation, and self-conscious constructions of community. Part One examines the performance genres that have drawn audiences from throughout the city. Part Two focuses on the areas of neighborhood, leisure, and work, examining the processes by which urban residents use a sense of identity to organize their activities and bring meaning to their lives. Part Three links these experiences within Banaras to a series of "larger worlds," ranging from l...