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Store-operated Ca2+ entry (SOCE) pathways
Store-operated Ca2+ entry (SOCE) serves to control essential functions throughout the human body and represents a novel and attractive target for therapeutic intervention. This book provides an extensive overview of the role of SOCE pathways in Molecular Physiology and Cell Biology, as well as their clinical significance. (Patho)physiological principles and emerging therapeutic strategies are delineated in a way that is valuable both for the education of graduate students in advanced Cell Biology/Molecular Physiology and for the promotion of innovative research and developments in the clinical/therapeutic fields. A comprehensive, clear and elaborate representation of current concepts is provided, including a pathophysiological section arranged in a tissue/organ/system-oriented manner. The book is intended for basic researchers specializing in cell signaling, ion transport, or pharmacology, as well as biomedical scientists and clinicians with a focus on immunology, neurology or cardiology.
Neuronal Self-Defense: Compensatory Mechanisms in Neurodegenerative Disorders
Neurodegenerative disorders are characterized by the progressive loss of specific populations of neurons with consequent deterioration of brain's function and dramatic impact on human behavior. At present, there are no effective cures for neurodegenerative diseases. Because unambiguous diagnosis is possible only after manifestation of symptoms, when a large proportion of neurons has been already lost, therapies are necessarily confined to alleviation of symptoms. Development of cures halting the disease course is hampered by our rudimentary understanding of the etiopathology. Most neurodegenerative disorders are sporadic and age-related and - even for those of known genetic origin - the mech...
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Ion Transport and Membrane Interactions in Vascular Health and Disease
Ion Transport and Membrane Interactions in Vascular Health and Disease, Volume 90 in the Current Topics in Membranes series, highlights advances in the field, with this new volume including chapters on an Introduction to Ion transport and membrane interactions in vascular health and disease, Endothelial cell microdomains of Ca2+ and metabolism, Cytoplasmic nanojunctions between smooth muscle organelles control specific Ca2+ signaling, TRPML channels in coronary vascular phenotypic modulation and calcification, Local voltage-gated Ca2+ channel regulation of vascular smooth muscle in diabetes, Biphasic changes in smooth muscle Ca2+ transporters during the progression of coronary atherosclerosis, Role of K+ channels in atherosclerosis, and more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Current Topics in Membranes series - Updated release includes the latest information on Ion Transport and Membrane Interactions in Vascular Health and Disease
Mitochondrial Medicine
This second edition offers 88 chapters divided among three volumes providing the most comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine. Volume II guides readers through chapters on mitochondrial dysfunction, functional’ mitochondria, mitochondrial retrograde, mitochondrial dNTP pool quantification, mitochondrial ADP-ribosylation, blue-native gel approach, 3D optical cryo-imaging method, mitochondrial ATP and ROS production, protocol for untargeted metabolomic analysis, and methods for analysis of nitrotyrosine-containing proteins. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Mitochondrial Medicine, Second Edition, Volume 2: Assessing Mitochondria aims to be a comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine.
