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MARS: Mutation-adjusted Risk Score for Advanced Systemic Mastocytosis
Abstract: PURPOSE To develop a risk score for patients with advanced systemic mastocytosis (AdvSM) that integrates clinical and mutation characteristics. PATIENTS AND METHODS The study included 383 patients with AdvSM from the German Registry on Disorders of Eosinophils and Mast Cells (training set; n = 231) and several centers for mastocytosis in the United States and Europe, all within the European Competence Network on Mastocytosis (validation set; n = 152). A Cox multivariable model was used to select variables that were predictive of overall survival (OS). RESULTS In multivariable analysis, the following risk factors were identified as being associated with OS: age greater than 60 years...
Cytogenetic and Molecular Aberrations and Worse Outcome for Male Patients in Systemic Mastocytosis
Abstract: In systemic mastocytosis (SM), the clinical features and survival vary greatly. Patient-related factors determining the outcome in SM are largely unknown. Methods: We examined the impact of sex on the clinical features, progression-free survival (PFS), and overall survival (OS) in 3403 patients with mastocytosis collected in the registry of the European Competence Network on Mastocytosis (ECNM). The impact of cytogenetic and molecular genetic aberrations on sex differences was analyzed in a subset of patients. Results: Of all patients enrolled, 55.3% were females. However, a male predominance was found in a subset of advanced SM (AdvSM) patients, namely SM with an associated hemato...
Family Punishment in Nazi Germany
In the Third Reich, political dissidents were not the only ones liable to be punished for their crimes. Their parents, siblings and relatives also risked reprisals. This concept - known as Sippenhaft – was based in ideas of blood and purity. This definitive study surveys the threats, fears and infliction of this part of the Nazi system of terror.
Protecting Motherhood
Robert G. Moeller is the first historian of modern German women to use social policy as a lens to focus on society's conceptions of gender difference and "woman's place." He investigates the social, economic, and political status of women in West Germany after World War II to reveal how the West Germans, emerging from the rubble of the Third Reich, viewed a reconsideration of gender relations as an essential part of social reconstruction. The debate over "woman's place" in the fifties was part of West Germany's confrontation with the ideological legacy of National Socialism. At the same time, the presence of the Cold War influenced all debates about women and the family. In response to the "...
The Biology and Treatment of Myeloid Leukaemias
This book is a printed edition of the Special Issue "The Biology and Treatment of Myeloid Leukaemias" that was published in IJMS
Reinhard Hauff
Reinhard Hauff (*1939) begann in der Fernsehindustrie, in den 1970er und 1980er Jahren wurde er zu einem der bekanntesten Regisseure des deutschen Kinos. Reinhard Hauff geriet als Quereinsteiger in die bundesdeutsche Unterhaltungsbranche, lernte bei Michael Pfleghar und Rolf von Sydow, inszenierte den Kabarettisten Hanns Dieter Hüsch und drehte zupackende Personality Shows u. a. über Janis Joplin und Wilson Pickett , bevor er eine Wende vollzog, um sich mit dokumentarischen Arbeiten wie "Untermann – Obermann" (1969) oder "Offener Haß gegen Unbekannt" (1970) dezidiert der sozialen Wirklichkeit zu stellen. Seine Filme in dieser Zeit, wie "Die Verrohung des Franz Blum" (1974) und "Paule Pa...
Church of Spies
The heart-pounding history of how Pope Pius XII -- often labeled "Hitler's Pope" -- was in fact an anti-Nazi spymaster, plotting against the Third Reich during World War II. The Vatican's silence in the face of Nazi atrocities remains one of the great controversies of our time. History has accused wartime pontiff Pius the Twelfth of complicity in the Holocaust and dubbed him "Hitler's Pope." But a key part of the story has remained untold. Pope Pius in fact ran the world's largest church, smallest state, and oldest spy service. Saintly but secretive, he sent birthday cards to Hitler -- while secretly plotting to kill him. He skimmed from church charities to pay covert couriers, and surreptitiously tape-recorded his meetings with top Nazis. Under his leadership the Vatican spy ring actively plotted against the Third Reich. Told with heart-pounding suspense and drawing on secret transcripts and unsealed files by an acclaimed author, Church of Spies throws open the Vatican's doors to reveal some of the most astonishing events in the history of the papacy. Riebling reveals here how the world's greatest moral institution met the greatest moral crisis in history.
Anemia in the Elderly
Anemia in the elderly has been properly defined as the silent epidemic, representing 3 million people in the United States aged 65 years and older. Incidence and prevalence of this condition increase with age. It differs in its etiology, pathogenesis and treatment from anemia in children and younger adults. Anemia is associated with reduced survival, increased risk of functional dependence and hospitalization, increased risk of congestive heart failure and stage renal disease and cognitive disorders. Approximately 70% of anemia in older individuals is reversible.
