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L'Øneïdå
Dans la cité de Ciprice, au coeur du royaume de Riwalenn, quatre jeunes Désignés vont devoir affronter leur destin. Leilani, garce notoire, Ceylan, sans-don et les jumeaux orphelins, passent ensemble les trois épreuves qui leur permettront de devenir Initiés. Tout devient plus difficile, lorsqu'un étranger, secrètement obsédé par l'Øneïdå, l'Élu de la Prophétie, vient les perturber. Pour l'étranger, l'Élu est à Ciprice. Il n'y a pas de doute, la cité semble protégée par une magie qu'il n'a croisée nulle part ailleurs. Mais la prophétie suscite quête et curiosité autant au royaume de Riwalenn que dans l'empire voisin, Catwallon. Ces deux nations, régulièrement en conflit au cours des âges, ont récemment conclu un traité de paix...
Les contes de jasmin
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Successful Drug Discovery, Volume 4
Provides unique insider insight into the current drug development process, and what it takes to achieve success In this fourth volume in the series, inventors and primary developers of drugs that made it to the market continue telling the story of the drugs? discovery and development, and discuss the sometimes twisted route from the first drug candidate molecule to the final marketed one. Beginning with a general section addressing overarching topics for drug discovery, the book offers seven chapters that feature selected case studies describing recently introduced drugs or drug classes. These include small molecule drugs as well as biopharmaceuticals and range across different therapeutic f...
Innovations for Next-Generation Antibody-Drug Conjugates
Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the innovations that will enable them. The book inspires the future by integrating the field’s history with novel strategies and cutting-edge technologies. While the book primarily addresses ADCs for solid tumors, the last chapter explores the emerging interest in using ADCs to treat other diseases. The therapeutic rationale of ADCs is strong: to direct small molecules to the desired site of action (...
Disparities in Mental Health
Health inequity not only has tremendous economic burden, but also impairs the foundations of social justice in any society. The current state of scientific knowledge supports the existence of significant inequities and disparities between different social groups. A significant part of our understanding of the health inequities lies in the realm of physical diseases, though mental health’s nature makes it more vulnerable to disparities. Mental health issues are sensitive matters that require additional trust, cultural appropriateness, acceptance, and support from healthcare providers and healthcare systems. As a result, not only mental health patients are at risk of disparities that exist in physical diseases, but they also face other challenges such as social stigma, language barriers, and fear of treatment that could result in disparities. Considering all these, we need to understand where the inequities are in the realm of mental health and who is being affected the most. We also need to know the existing policies and their effectiveness and efficiency. And with all these, then, we could plan how to decrease mental health disparities and provide welfare to all.
Chemical Linkers in Antibody-Drug Conjugates (ADCs)
Chemical Linkers in Antibody-Drug Conjugates aims to shine a detailed light on the various key attributes of chemical linkers in ADCs, for drug-to-antibody ratio, for stability, for release mechanism of payload, for pharmacokinetics, for stability determination, and for efficacy and safety.
Pharmacology of the WNT Signaling System
This book reflects the state of the art of our understanding of the WNT signaling system, which comprises a network of signaling pathways initiated by the secreted WNT lipoglycoproteins, which are crucial for embryonal development, stem cell regulation, tissue homeostasis and repair. Dysfunction of this evolutionarily conserved signaling system leads to many diseases including developmental disorders, diverse forms of cancer, fibrosis, neurodegenerative disease and many more. The WNT signaling system is built upon 19 mammalian, secreted WNT lipoglycoproteins that interact with a plethora of distinct receptors, such as the G protein-coupled receptors called Frizzleds (FZD1-10), LDL receptor-l...
Chemical and Biological Synthesis
Synthetic chemistry plays a central role in many areas of chemical biology; utilising recent case studies, the goal of Chemical and Biological Synthesis is to highlight the full impact that the preparation of novel reagents can have in chemical biology. Covering the synthetic approaches that can be applied across the whole field of chemical biology, this book provides synthetic chemists with the broader context to which their work contributes and the biological questions that can be addressed through it. An ideal guide for postgraduate students and researchers in synthetic organic chemistry and chemical biology, Chemical and Biological Synthesis introduces synthetic techniques and methods to those who wish to incorporate synthesis for the first time in their biology-focused research programmes.
Prejudice, Stigma, Privilege, and Oppression
This book addresses the ways in which clinical psychologists ought to conceptualize and respond to the prejudice and oppression that their clients experience. Thus, the link between prejudice and oppression to psychopathology is explored. Basic scientific information about prejudice is reviewed, and the current status of the major minority groups is explored. Chapters examine the role of prejudice and oppression in institutional structures such as the Diagnostic and Statistical Manual of Mental Disorders and professional organizations. The discussion addresses ways to assess these phenomena in individual cases and how to intervene in psychotherapy. The book ventures to evaluate the status of the profession of psychology with respect to prejudice, stigmatization, and oppression by critically examining evidence that the profession has responded adequately to these social problems. These issues are hard to talk about and are not well talked about in the field. This book is a push in the right direction.
Radiation in Bioanalysis
This book describes the state of the art across the broad range of spectroscopic techniques used in the study of biological systems. It reviews some of the latest advances achieved in the application of these techniques in the analysis and characterization of small and large biological compounds, covering topics such as VUV/UV and UV-visible spectroscopies, fluorescence spectroscopy, IR and Raman techniques, dynamic light scattering (DLS), circular dichroism (CD/SR-CD), pulsed electron paramagnetic resonance techniques, Mössbauer spectroscopy, nuclear magnetic resonance, X-ray methods and electron and ion impact spectroscopies. The second part of the book focuses on modelling methods and illustrates how these tools have been used and integrated with other experimental and theoretical techniques including also electron transfer processes and fast kinetics methods. The book will benefit students, researchers and professionals working with these techniques to understand the fundamental mechanisms of biological systems.
