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Computational Analysis of the Mammalian Cis-regulatory Landscape
Improvements in DNA sequencing technologies have made it possible to determine the genetic makeup of many organisms. Computational analyses of the massive amounts of sequence data available have produced many insights into evolutionary and developmental biology. For example, comparison of the full genome sequences of human and mouse discovered that the majority of functional sequence in the human genome does not code for protein. Much of this functional non-coding sequence appears to act in a regulatory role, dictating the precise tissues and developmental time points in which each protein should be produced. This dissertation describes three major contributions to the computational analysis...
The Domesticated Penis
"The Domesticated Penis is the first anthropological history of the penis, incorporating evidence from evolutionary theory, primatology, archaeology, and cultural anthropology"--
Family History of Nathaniel Z. Martin, 1841-1992
Christian Martin (b. 1669) was born in Switzerland. He married Ells/Elizabeth in 1672 and they had six children. Their son, David Martin (1691-1784) was born in Switzerland and married four times. He fathered twelve children. He came to Philadelphia in 1727, settling in Weaverland, Pennsylvania. David's descendant Nathaniel Zimmerman Martin (1841-1923) was born in Weaverland. He married Maria S. Sauder and they had seven children. Descendants still live in Pennsylvania.
Next-Generation Sequencing Data Analysis
RNA-seq: both bulk and single-cell (separate chapters) Genotyping and variant discovery through whole genome/exome sequencing Clinical sequencing and detection of actionable variants De novo genome assembly ChIP-seq to map protein-DNA interactions Epigenomics through DNA methylation sequencing Metagenome sequencing for microbiome analysis
The Report of the British and Foreign Bible Society
Vols. 1-64 include extracts from correspondence.
Family History of Christian Burkholder, 1746-1990
Christian Burkholder (1746-1809), a son of Christian Burkholder, was born in Switzerland. His father died during arrangements to move the family to America, so his mother immigrated with the children, settling in Pennsylvania. He married Anna Groff, a daughter of Daniel Groff, before 1767. They had nine children. They were Mennonites, and descendants appear to live mostly in Pennsylvania.
Ancestors and Descendants of Moses Musser Horning and Lavina Musser Gehman
Moses M. Horning (1830-1906) was born on his father's farm in Brecknock Twp., along the Allegheny Creek, Pennsylvania. He was a son of Joseph and Fannie Mosser Horning. He married Lavina M. Gehman (1832- 1897) in 1853. She was a daughter of Benjamin B. and Elizabeth (Musser) Gehman. Early ancestors of the Horning family came origi- nally from Germany in the early 18th century. The emigrant ancestor of the Gehman family, Christian Gehman, came from Switzerland in 1754. Members of this family are mennonites. Descendants live in Pennsylvania, Ohio, Illinois, Maryland, Canada and elsewhere.
