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Textbook of Drug Design and Discovery, Fifth Edition
Building on the success of the previous editions, the Textbook of Drug Design and Discovery, Fifth Edition, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The information is presented in an up-to-date review form with an underlying and fundamental focus on the educational aspects. Beginning with an introduction to drug design and discovery, the first eight chapters cover molecular recognition, ligand-based drug design, and biostructure-based drug design. The authors also discuss drug-like properties and decision making in medicinal che...
Protein and Sugar Export and Assembly in Gram-positive Bacteria
This book focuses on the envelope of Gram-positive bacteria including its composition, the latest discoveries in the mechanisms behind its assembly, and its role in pathogenesis. Furthermore, new applications in biotechnology and vaccine development involving these bacteria are discussed in detail. This concise volume consists of eleven chapters by prominent experts in the field, which review the latest findings and current state of knowledge on a range of diverse yet interlinked aspects. This book is written for all researchers, clinicians and technicians engaged in basic or applied science projects on Gram-positive bacteria.
Mass Spectrometry for the Analysis of Pesticide Residues and their Metabolites
Provides an overview of the use of mass spectrometry (MS) for the analysis of pesticide residues and their metabolites. Presents state of the-art MS techniques for the identification of pesticides and their transformation products in food and environment Covers important advances in MS techniques including MS instrumentation and chromatographic separations (e.g. UPLC, HILIC, comprehensive GCxGC) and applications Illustrates the main sample preparation techniques (SPE, QuEChERS, microextraction) used in combination with MS for the analysis of pesticides Describes various established and new ionization techniques as well as the main MS platforms, software tools and mass spectral libraries
Molecular Dynamics of Biomembranes
Protein insertion and translocation, intracellular traffic and sorting of membranes and their components, and lipid-protein interactions were the main topics of the Advanced Study Institute on "Molecular Dynamics of Membranes", which was held in June 1995 in Cargese, Corsica, France. The course, co-sponsored by NATO and FEBS, was the fifth in a series that started in 1987 and takes place every two years in the Institut d'Etudes Scientifiques in Cargese. This Institute, ideally situated and fully equiped for this type of scientific meeting has greatly contributed to the great success of the courses. Of course, also the outstanding contributions of a large number of well known scientists and t...
From Fundamental Genomics to Systems Biology
Accompanying CD-ROM contains text.
Bacterial Cell Walls and Membranes
This book provides an up-to-date overview of the architecture and biosynthesis of bacterial and archaeal cell walls, highlighting the evolution-based similarities in, but also the intriguing differences between the cell walls of Gram-negative bacteria, the Firmicutes and Actinobacteria, and the Archaea. The recent major advances in this field, which have brought to light many new structural and functional details, are presented and discussed. Over the past five years, a number of novel systems, e.g. for lipid, porin and lipopolysaccharide biosynthesis have been described. In addition, new structural achievements with periplasmic chaperones have been made, all of which have revealed amazing details on how bacterial cell walls are synthesized. These findings provide an essential basis for future research, e.g. the development of new antibiotics. The book’s content is the logical continuation of Volume 84 of SCBI (on Prokaryotic Cytoskeletons), and sets the stage for upcoming volumes on Protein Complexes.
Functions and Mechanisms of Bacterial Protein Homeostasis and Stress Responses
The Cover Image for This Research Topic is Used With Permission of the Authors and Publishers of the Following Article: Winkler J, Seybert A, König L, Pruggnaller S, Haselmann U, Sourjik V, Weiss M, Frangakis AS, Mogk A, Bukau B.EMBO J. 2010 Mar 3;29(5):910-23. doi: 10.1038/emboj.2009.412. Epub 2010 Jan 21
