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A YAP/TAZ-ARHGAP29-RhoA Signaling Axis Regulates Podocyte Protrusions and Integrin Adhesions
Abstract: Glomerular disease due to podocyte malfunction is a major factor in the pathogenesis of chronic kidney disease. Identification of podocyte-specific signaling pathways is therefore a prerequisite to characterizing relevant disease pathways and developing novel treatment approaches. Here, we employed loss of function studies for EPB41L5 (Yurt) as a central podocyte gene to generate a cell type-specific disease model. Loss of Yurt in fly nephrocytes caused protein uptake and slit diaphragm defects. Transcriptomic and proteomic analysis of human EPB41L5 knockout podocytes demonstrated impaired mechanotransduction via the YAP/TAZ signaling pathway. Further analysis of specific inhibitio...
Luxury Cars Coloring Book
Imagine yourself behind the wheel of a Porsche 911 GT2 Twin-Turbo Coupe! Here are the cars most of us just dream about — sleek, fast, fabulous machines that cost a small fortune! Thirty precisely and accurately rendered illustrations portray the legendary luxury cars that race through our imaginations: Mercedes-Benz SLR McLaren Coupe, BMW Z8 Convertible, Maserati Spyder 2-door Convertible/Roadster, Rolls-Royce Phantom 4-door Sedan, Jaguar XJ220, Bugatti EB 110S 2-door Coupe, and other automotive marvels. Detailed captions provide specs and other information (including top speed and acceleration time). And they come in any colors you choose to make them!
Moniteur des dates
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The Global Financial Crisis
Contents: (1) Recent Developments and Analysis; (2) The Global Financial Crisis and U.S. Interests: Policy; Four Phases of the Global Financial Crisis; (3) New Challenges and Policy in Managing Financial Risk; (4) Origins, Contagion, and Risk; (5) Effects on Emerging Markets: Latin America; Russia and the Financial Crisis; (6) Effects on Europe and The European Response: The ¿European Framework for Action¿; The British Rescue Plan; Collapse of Iceland¿s Banking Sector; (7) Impact on Asia and the Asian Response: Asian Reserves and Their Impact; National Responses; (8) International Policy Issues: Bretton Woods II; G-20 Meetings; The International Monetary Fund; Changes in U.S. Reg¿s. and Regulatory Structure; (9) Legislation.
Molecular Imaging of Small Animals
This book examines the fundamental concepts of multimodality small-animal molecular imaging technologies and their numerous applications in biomedical research. Driven primarily by the widespread availability of various small-animal models of human diseases replicating accurately biological and biochemical processes in vivo, this is a relatively new yet rapidly expanding field that has excellent potential to become a powerful tool in biomedical research and drug development. In addition to being a powerful clinical tool, a number of imaging modalities including but not limited to CT, MRI, SPECT and PET are also used in small laboratory animal research to visualize and track certain molecular processes associated with diseases such as cancer, heart disease and neurological disorders in living small animal models of disease. In vivo small-animal imaging is playing a pivotal role in the scientific research paradigm enabling to understand human molecular biology and pathophysiology using, for instance, genetically engineered mice with spontaneous diseases that closely mimic human diseases.
The Big Trivia Quiz Book
Put your general knowledge to the test, and impress your family and friends with your astonishing brainpower and trivia genius. An addictive quiz book for all the family featuring 10,000 questions, The Big Quiz Book has something for everyone. With 10 different general knowledge categories - from Science & Technology, Art & Literature, and Natural History, to Food & Drink, Film & TV, and Sport & Leisure - and three increasing levels of difficulty, it offers a fresh and up-to-the-minute quizzing experience that will educate and entertain all the family. Bursting with fascinating facts to boost your trivia knowledge, whatever your specialist subject or your nemesis topic, The Big Quiz Book is perfect for home entertainment and virtual pub quizzes. You won't be able to put it down!
Germans to America
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Made in Trollhattan
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