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A YAP/TAZ-ARHGAP29-RhoA Signaling Axis Regulates Podocyte Protrusions and Integrin Adhesions
Abstract: Glomerular disease due to podocyte malfunction is a major factor in the pathogenesis of chronic kidney disease. Identification of podocyte-specific signaling pathways is therefore a prerequisite to characterizing relevant disease pathways and developing novel treatment approaches. Here, we employed loss of function studies for EPB41L5 (Yurt) as a central podocyte gene to generate a cell type-specific disease model. Loss of Yurt in fly nephrocytes caused protein uptake and slit diaphragm defects. Transcriptomic and proteomic analysis of human EPB41L5 knockout podocytes demonstrated impaired mechanotransduction via the YAP/TAZ signaling pathway. Further analysis of specific inhibitio...
Collective Creativity
Creativity in organizations has become a key topic of organizational research. This work expands on existing research by exploring creativity in the dynamics of social networks. Collective creativity is introduced as a central part of organizational learning and seen as the expression of creativity on the collective level. The research is able to empirically assess creativity in the development of social structures. For the assessment of creativity this work applies a longitudinal study design by combining social network analysis with creativity studies. The approach enables to relate creativity indicators with social network measures. It is based on an empirical study of innovation projects in the automotive industry and thereby extends existing research and theories on creativity, social network dynamics and organizational learning.
Catalogue of Publications Issued by the Government of the United States
February issue includes Appendix entitled Directory of United States Government periodicals and subscription publications; September issue includes List of depository libraries; June and December issues include semiannual index
Aeolian and Adhesion Morphodynamics and Phytoecology in Recent Coastal and Inland Sand and Snow Flats and Dunes from Mainly North Sea and Baltic Sea to Mars and Venus
The outline of the aeolian and adhesion morphodynamics and phytoecology in recent coastal and inland sand and snow flats and dunes includes examples from the North Sea coast (Netherlands, Germany and Denmark), Baltic Sea coast (Germany, Poland, Russia and Lithuania), snow flats on ice plates covering frozen inland lakes (Germany), Great Sand Dunes aeolian dune field and Medano Creek sand flat (Colorado/USA), Red River sand flat (Texas and Oklahoma/USA); and Mars, Venus, Titan, Triton and other bodies in the solar system of planets and satellites. The actual geological, geomorphological and physical geographical study of modern dune fields and fluvial or marine sand flats permits also the comparative palaeoenvironmental interpretation of ancient dune fields and sand flats in fluvial basins in Buntsandstein (Lower Triassic), Rotliegend (Lower Permian) and Keuper (Upper Triassic). Lists of References, Key Words and Illustrations. More than 10,000 References.
Southern Baltic Coastal Systems Analysis
This book gives an overall analysis of the current knowledge status about structures, functions, utilization for German Baltic coast ecosystems. The main focus of this book is on the aquatic area, but land/sea interactions as well as river outfalls are included as well. Characteristic for this book is the inclusion of social science aspects. Approximately one third of its extent will be about the ecosystem services. In this segment the results of the last 6 years are presented in which a comprehensive quantification of the social relevance of ecosystems was carried out covering the entire area of the German Baltic Sea. This part builds directly on the results of scientific investigations and...
