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Ruxolitinib for the Treatment of Patients with Steroid-refractory GVHD
Abstract: For patients with hematologic malignancies and disorders, allogeneic hematopoietic stem cell transplantation offers a potentially curative treatment option. Many patients develop graft-versus-host disease (GVHD), a serious complication and leading cause of nonrelapse mortality. Corticosteroids are the standard first-line treatment for GVHD; however, patients often become steroid-refractory or remain corticosteroid-dependent. New second-line treatment options are needed to improve patient outcomes. Here we review the role of JAK1 and JAK2 in acute and chronic GVHD. We also describe the study designs of the Phase II REACH1 (NCT02953678) and the Phase III REACH2 (NCT02913261) and REACH3 (NCT03112603) clinical trials that are currently recruiting patients to evaluate the JAK1/JAK2 inhibitor ruxolitinib in patients with corticosteroid-refractory acute or chronic GVHD
My Life Story
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Glad to Be Here
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Brian Griffin
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Making Nature, Shaping Culture
For ages, farmers have domesticated plant varieties, while scientists have "made" nature through hybridization and other processes. This give and take-mediated through negotiations, persuasion, the marketplace, and even coercion-has resulted in what we call "nature" and has led to a homogenization of plant crops. Yet homogenization has led to new problems: genetic vulnerability, and the lack of systems to maintain plant germplasm of varieties no longer grown in the fields. This book addresses issues previously viewed as primarily technical concerning the germplasm debate: that is, how, what, and where to store the range of genetic materials necessary to reproduce plants. By examining Brazil,...
Pizzo and Poplack's Pediatric Oncology
"This authoritative reference is a comprehensive resource on the biology and genetics of childhood cancer as well as its diagnosis, multimodal treatment, as well as long-term management of young patients with cancer. Also addressed are a broad array of topics on the supportive and psychosocial aspects of care of children and families. Covering virtually every aspect of the breadth and depth of childhood cancer, this reference provides expert guidance on state-of-the-art, multidisciplinary care for children and families"--
Olympia High School
In 1907, William Winlock Miller High School, known as Olympia High School, first opened its doors to the sons and daughters of the South Puget Sound area's pioneer families. Three campuses and a century later, the school remains a vibrant part of the community and a herald of academic and athletic excellence across the state. A walk through time, this volume illustrates the pictorial history of the buildings and campuses, well-known personalities, student life, and traditions that have left an indelible mark on the history of the region. This book touches upon the many institutions that have endured and pays homage to the customs that have been lost or evolved over the decades. From the original campus adjacent to the current state capitol, to the 43 years on Capitol Way, to the dairy farm evolving into a 15-acre complex, now home to William Winlock Miller High School, this work is the most comprehensive study of the history of Olympia High School to date.
Institutional Choice and Global Commerce
Why do institutions emerge, operate, evolve and persist? Institutional Choice and Global Commerce elaborates a theory of boundedly rational institutional choice that explains when states USE available institutions, SELECT among alternative forums, CHANGE existing rules, or CREATE new arrangements (USCC). The authors reveal the striking staying power of the institutional status quo and test their innovative theory against evidence on institutional choice in global commerce from the nineteenth through the twenty-first centuries. Cases range from the establishment in 1876 of the first truly international system of commercial dispute resolution, the Mixed Courts of Egypt, to the founding and operation of the General Agreement on Tariffs and Trade, the World Trade Organization, and the International Accounting Standards Board. Analysts of institutional choice henceforth must take seriously not only the distinct demands of specific cooperation dilemmas, but also the wide array of available institutional choices.
The Politics of International Economic Relations
The first and definitive book of its kind, Joan Spero's The Politics of International Economic Relations has been fully updated to reflect the sweeping changes in the international arena. With the expertise of co-author Jeffrey Hart, the fifth edition strengthens the coverage of political and economic relations since the end of the Cold War, economic polarization in developing nations and the roots of economic decline in centrally planned economies. A new chapter on industrial policy and competitiveness debates further illustrates the changing dynamics of International Political Economy. Ideal as a supplement to the International Relations course or as the core text in International Political Economy, Spero and Hart's The Politics of International Economic Relations continues to give students the breadth and depth of scholarship needed to understand the politics of world economy.
