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Clinical Manual of Blood and Bone Marrow Transplantation
Providing the practicing and trainee hematologist with a practical and immediately applicable compendium of answers the Clinical Manual of Blood and Bone Marrow Transplantation covers the spectrum of the hematopoietic cell transplant specialty, in particular practical issues in transplant patient care, and the set up and functioning of a transplant program. Supplies the practicing and trainee hematologist with a practical and immediately applicable compendium of answers to clinical questions Covers the spectrum of the hematopoietic cell transplant specialty, in particular practical issues in transplant patient care, and the set up and functioning of a transplant program Contains concise chapters written with a focus on tables, algorithms and figures to aid rapid referral Benefits from expert contributions from an international authorship
Allogeneic Stem Cell Transplantation
Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.
Extracorporeal Photopheresis
Extracorporeal photopheresis (ECP) is the first FDA approved cellular photoimmunotherapy for cancer, namely cutaneous T-cell lymphoma, and has demonstrated efficacy in various diseases that have a suspected involvement of pathogenic T-cells including prevention and treatment of acute and chronic graft-versus-host disease, organ transplant rejection, selected autoimmune diseases and Sezary syndrome. In ECP, patient’s blood mononuclear cells are collected, exposed to ultraviolet light in the presence of extracorporeally administered liquid 8-methoxypsoralen and reinfused. Besides its considerable efficacy ECP has an exceptional safety profile, does not cause general immunosuppression and thu...
Ruxolitinib for the Treatment of Patients with Steroid-refractory GVHD
Abstract: For patients with hematologic malignancies and disorders, allogeneic hematopoietic stem cell transplantation offers a potentially curative treatment option. Many patients develop graft-versus-host disease (GVHD), a serious complication and leading cause of nonrelapse mortality. Corticosteroids are the standard first-line treatment for GVHD; however, patients often become steroid-refractory or remain corticosteroid-dependent. New second-line treatment options are needed to improve patient outcomes. Here we review the role of JAK1 and JAK2 in acute and chronic GVHD. We also describe the study designs of the Phase II REACH1 (NCT02953678) and the Phase III REACH2 (NCT02913261) and REACH3 (NCT03112603) clinical trials that are currently recruiting patients to evaluate the JAK1/JAK2 inhibitor ruxolitinib in patients with corticosteroid-refractory acute or chronic GVHD
Chronic Graft Versus Host Disease
Chronic graft versus host disease (GVHD) is the most common complication of allogenic bone marrow transplantation. Because of the protracted clinical course of chronic GVHD, transplant centers and hematology/oncology offices are inadequately equipped to manage these immuno-incompetent patients with a multi-system disorder. Practitioners need to be able to recognize and effectively manage chronic GVHD as a late effect of more than half of allogenic transplantations. The text is oriented for the clinician, with chapters covering staging, organ site and system-specific manifestations, treatment options, and supportive care. Drs Georgia B. Vogelsang and Steven Z. Pavletic have been pioneers in the recognition of the multi-organ complexity of this disease and have gathered the input of a variety of subspecialist physicians for this book. This book fills the gap in practical literature on chronic GVHD, providing a comprehensive, up-to-date, and clinically relevant resource for anyone who deals with cancer patients post-transplant.
Wintrobe's Clinical Hematology
Now available in a thoroughly revised Twelfth Edition, Wintrobe's Clinical Hematology continues to be an industry leader with its ability to correlate basic science with the clinical practice of hematology. With the first edition of Wintrobe's Clinical Hematology published in 1942 clearly establishing hematology as a distinct subspecialty of Internal Medicine, the latest edition continues the influence of the Wintrobe name and helps to set this book apart from the competition.With its strong focus on the clinical aspects of hematology, the book has generated a strong following among internists and general practitioners who want a single resource to consult for their patients who present any blood related disorder. The Twelfth Edition is in full color for the first time, boasts a new editorial team, and includes expanded coverage of new medications and four new chapters on Newborn Anemias, Pathology of LHC, Spleen Tumors, and Myeloproliferative Disorders and Mast Cell Disease. A companion Website will offer the fully searchable text and an image bank.
Right to Recover
"Yvonne Perry's book enrages and inspires: it leaves you with the feeling that something must be done, that it can be done, and that it will be done-because we will do it. This book changes the equation." -Don C. Reed, Roman Reed Spinal Cord Injury Research Act It is such a pleasure to work with a writer like Yvonne Perry. She has truly researched the research and spent hundreds of hours to find the facts to share with the readers of RIGHT TO RECOVER. Over the years I have read literally thousands of articles and documents from around the world about this subject and RIGHT TO RECOVER is the most complete work I have ever read. It provides an honest evaluation and asks readers to consider the...
Hematopoietic Cell Transplantation for Malignant Conditions
Get a quick, expert overview of hematologic and non-hematologic malignancies for which hematopoietic cell transplantation is a treatment option. Drs. Qaiser Bashir and Mehdi Hamadani provide easy-to-find information on basic science of hematopoietic cell transplantation, pharmacology, workflows and procedures, possible complications and side effects, in addition to the role of HCT in conjunction with clinical cellular therapy. Discusses high-dose chemotherapeutic regimens and radiation therapy, patient and donor selection and workup, as well as other key aspects of hematopoietic cell transplantation. Includes practical information on complications, infectious disease, and special populations such as patients with HIV infection. Consolidates today’s available information in this fast-changing area into one convenient resource.
AACR 2022 Proceedings: Part B April 11-13
The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world.
