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Stress Response
Mammalian cells have evolved a complex multicomponent machinery that enables them to sense and respond to a wide variety of potentially toxic agents present in their environment. These stress responses are often associated with an increased cellular capacity to tolerate normally lethal levels of an insult. The realization that the mammalian stress response may be intimately linked with many human diseases, including rheumatoid arthritis, ischemia, fever, infection, and cancer, has led to an explosion of interest in this research area. Stress Response: Methods and Protocols brings together a diverse array of practical methodologies that may be employed to address various aspects of the respon...
Prevention
Prevention magazine provides smart ways to live well with info and tips from experts on weight loss, fitness, health, nutrition, recipes, anti-aging & diets.
Cancer Research
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Advances in Molecular and Pharmacological Mechanisms of Novel Targeted Therapies for Melanoma
Malignant melanoma is the most aggressive type of skin cancer with invasive growth patterns. Recent advances in melanoma management have focused on cell growth, proliferation, migration, and survival biomarkers. Numerous FDA-approved molecular-targeted therapies, such as tyrosine kinase inhibitors (TKIs), have been developed targeting genetic biomarkers that play a critical role in tumorigenesis when overexpressed. The use of targeted therapies as an alternative or adjuvant to immunotherapy has revolutionized the management of metastatic melanoma. Although this treatment strategy is more efficacious and less toxic than traditional therapies, targeted therapies are less effective after prolonged treatment due to acquired resistance given the mutations and activation of resistant mechanisms in melanoma tumors. In this sense, identifying novel target therapies and repositioned drugs that could modulate the disease progression, the potential molecular and pharmacological mechanisms of therapies are of utmost interest.
Manipal Interdisciplinary Health Science and Technical Reports-2023
The “Manipal Interdisciplinary Health Science and Technical Reports-2023” is a comprehensive compilation of cutting-edge research and innovative findings across the fields of health sciences and technology. This edition presents a diverse array of studies conducted by experts at Manipal Academy of Higher Education, showcasing advancements in medical research, biotechnology, healthcare innovations, and technical applications. Each report within this volume highlights interdisciplinary approaches and collaborative efforts aimed at addressing some of the most pressing challenges in health and technology today. Ideal for researchers, practitioners, and students, this collection serves as a valuable resource for those seeking to stay at the forefront of scientific and technical progress.
