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Prognostic Implications of Dual Tracer PET/CT: PSMA Ligand and [18F]FDG PET/CT in Patients Undergoing [177Lu]PSMA Radioligand Therapy
Abstract: Background Prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) with 177Lu-labeled PSMA ligands has achieved remarkable results in advanced disease stages of metastatic castration-resistant prostate cancer (mCRPC). However, not all patients benefit from this therapy. Different treatment responses could be explained by tumor heterogeneity triggered by progression and the number of prior treatments. PSMA-negative lesions can be missed on PSMA ligand PET/CT, which subsequently results in an underestimation of tumor burden. Conversely, high FDG uptake may also be an indicator of tumor aggressiveness and thus a poor prognostic marker for response to RLT and overa...
Differential Diagnosis of Parkinsonism: a Head-to-head Comparison of FDG PET and MIBG Scintigraphy
Abstract: [18F]fluorodeoxyglucose (FDG) PET and [123I]metaiodobenzylguanidine (MIBG) scintigraphy may contribute to the differential diagnosis of neurodegenerative parkinsonism. To identify the superior method, we retrospectively evaluated 54 patients with suspected neurodegenerative parkinsonism, who were referred for FDG PET and MIBG scintigraphy. Two investigators visually assessed FDG PET scans using an ordinal 6-step score for disease-specific patterns of Lewy body diseases (LBD) or atypical parkinsonism (APS) and assigned the latter to the subgroups multiple system atrophy (MSA), progressive supranuclear palsy (PSP), or corticobasal syndrome. Regions-of-interest analysis on anterior pl...
Encyclopedia of Caves and Karst Science
The Encyclopedia of Caves and Karst Science contains 350 alphabetically arranged entries. The topics include cave and karst geoscience, cave archaeology and human use of caves, art in caves, hydrology and groundwater, cave and karst history, and conservation and management. The Encyclopedia is extensively illustrated with photographs, maps, diagrams, and tables, and has thematic content lists and a comprehensive index to facilitate searching and browsing.
Encyclopedia of Infectious Diseases
Discover how the application of novel multidisciplinary, integrative approaches and technologies are dramatically changing our understanding of the pathogenesis of infectious diseases and their treatments. Each article presents the state of the science, with a strong emphasis on new and emerging medical applications. The Encyclopedia of Infectious Diseases is organized into five parts. The first part examines current threats such as AIDS, malaria, SARS, and influenza. The second part addresses the evolution of pathogens and the relationship between human genetic diversity and the spread of infectious diseases. The next two parts highlight the most promising uses of molecular identification, ...
Endometriosis in Adolescents
Adolescent endometriosis is a previously overlooked disease in children, the true prevalence of which is still unknown but has been estimated between 19-73%. There are numerous initial challenges faced by adolescents suffering from delayed or undiagnosed endometriosis apart from experiencing chronic pain, such as: school/work absenteeism, false diagnoses/treatments, erroneous physician referrals, unnecessary radiological studies, radiation exposure, and emergency room visits as well as early exposure to narcotic pain medications and subsequent drug tolerance, resistance or even addiction. This text presents a clear history of physician and patient understanding and awareness of endometriosis...
The Rescue and Achievement of Refugee Scholars
This little book has been written at the suggestion of the Society for the Protection of Science and Learning. That body was the successor of the Academic Assistance Council which was formed in 1933 by heads of British Universities and learned Societies to assist scholars and scientists and investigators "who, on grounds of religion, political opinion or race, were unable to carryon their work in their own country". They were, at the time of the formation of the Society, particularly, but not exclusively, refugees from Nazi oppression, and deprived of their academic posts on one of these grounds. But they soon embraced refugees from other tyrannies. The British example was followed by simila...
