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Meta-analysis of Mechano-sensitive Ion Channels in Human Hearts: Chamber- and Disease-preferential MRNA Expression
Abstract: The cardiac cell mechanical environment changes on a beat-by-beat basis as well as in the course of various cardiac diseases. Cells sense and respond to mechanical cues via specialized mechano-sensors initiating adaptive signaling cascades. With the aim of revealing new candidates underlying mechano-transduction relevant to cardiac diseases, we investigated mechano-sensitive ion channels (MSC) in human hearts for their chamber- and disease-preferential mRNA expression. Based on a meta-analysis of RNA sequencing studies, we compared the mRNA expression levels of MSC in human atrial and ventricular tissue samples from transplant donor hearts (no cardiac disease), and from patients in...
Nucleic Acids as Molecular Diagnostics
By integrating technology, supporting infrastructure and efficient application, the all-in-one guide presents molecular diagnostics as an essential component of modern, personalized clinical practice. It considers all important aspects, from the hardware and software needed, to recent improvements in blood- and non-blood-based biomarker tests. Chapters on ethical challenges and a look at current trends and the latest innovations are also included. Bridging the gap between industry and academia, this is a highly useful resource for practitioners as well as for developers of modern, DNA- and RNA-based molecular diagnostics.
Uyghur Identity and Culture
Uyghur Identity and Culture brings together the work of scholars, activists, and native Uyghurs to explore the history and growing challenges that the Uyghur diaspora face across the globe in response to shifting government policies forbidding many forms of cultural expression in their homeland. The collection examines how and why the Uyghur diaspora, dispersed from their homeland to communities across Australia, Central Asia, Europe, Japan, Türkiye, and North America, now has the responsibility to preserve their language and cultural traditions so that these can be shared with future generations. The book critically investigates the government censorship of Uyghur literatures and Western m...
Microglia
This book presents a comprehensive toolkit of versatile techniques for studying microglia under different experimental settings along with a brief summary of knowledge, accumulated in microglial research over the last decades. Beginning with recently discovered roles of microglia in health and disease, the volume continues by covering in vitro analyses of microglia, in vivo studies, and “omics” analyses. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Microglia: Methods and Protocols serves as a vital guide to these important cells and an inspiration for scientists interested in expanding our knowledge of their role in the nervous system.
Advanced Nutrition
The explosion of knowledge about satiety and hunger has given new meaning to our understanding of the genetics of obesity. New interest in gene expression as related to nutrition and advances in the field of macronutrients has made the latest nutrition research intriguing. Advanced Nutrition: Macronutrients adopts an integrated approach to the understanding of macronutrient nutrition. It provides scientific foundations of the current findings on energy balance, protein need, gene expression, and carbohydrate and lipid use, and maintains emphasis on the biochemical and physiological basis for nutrient need.
The Politics of Muslim Cultural Reform
Adeeb Khalid offers the first extended examination of cultural debates in Central Asia during Russian rule. With the Russian conquest in the 1860s and 1870s the region came into contact with modernity. The Jadids, influential Muslim intellectuals, sought to safeguard the indigenous Islamic culture by adapting it to the modern state. Through education, literacy, use of the press and by maintaining close ties with Islamic intellectuals from the Ottoman empire to India, the Jadids established a place for their traditions not only within the changing culture of their own land but also within the larger modern Islamic world. Khalid uses previously untapped literary sources from Uzbek and Tajik as...
Never Marry a Woman with Big Feet
In this study the author analyses similarities, differences and contradictions in the cultural norms about gender expressed in proverbs she has found in oral and written sources from over 150 countries. Grouping the proverbs into categories as the female body, love, sex, childbirth and the female power, the author examines shared patterns in ideas about women and how men see them.
Uyghur Women Activists in the Diaspora
Presenting the life stories of ten Uyghur women, this book applies the techniques of narrative analysis to explore their changing worldviews and conversions to political engagement. Born and raised in East Turkestan/Xinjiang in the 1970s-90s, each woman, after personally experiencing incidents of ethnic discrimination, chose to leave China before 2005. Settling in a western country, they strive to become the voice of the Turkic people who are silenced or detained in the re-education camps. The narratives are based on interviews conducted online between 2020 and 2021, collected as a form of oral history. The book focuses on the escalating tensions, turning points experienced in their youth, and the religious, political and psychological factors that prompted their transformations in self-identity, ideology and the emergence of a new UyghurMuslim feminism. Through the women's stories, the book describes how women activists are navigating the competing reality constructions of the dire situation in the Uyghur Homeland and actively restorying a genocide to bring about social and political change.
