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Secreted Phosphoprotein 1 Expression in Retinal Mononuclear Phagocytes Links Murine to Human Choroidal Neovascularization
Abstract: Age-related macular degeneration (AMD) represents the most common cause of blindness in the elderly in the Western world. An impairment of the outer blood-retina barrier and a localized inflammatory microenvironment cause sprouting of choroidal neovascular membranes (CNV) in neovascular AMD that are in intimate contact with surrounding myeloid cells, such as retinal microglia, and ultimately lead to visual impairment. The discovery of novel target molecules to interfere with angiogenesis and inflammation is vital for future treatment approaches in AMD patients. To explore the transcriptional profile and the function of retinal microglia at sites of CNV, we performed a comprehensive...
International Labor
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Engineering and Physical Approaches to Cancer
Engineering and Physical Approaches to Cancer addresses the newest research at this interface between cancer biology and the physical sciences. Several chapters address the mechanobiology of collective and individual cell migration, including experimental, theoretical, and computational perspectives. Other chapters consider the crosstalk of biological, chemical, and physical cues in the tumor microenvironment, including the role of senescence, polyploid giant cells, TGF-beta, metabolism, and immune cells. Further, chapters focus on circulating tumor cells and metastatic colonization, highlighting both bioengineered models as well as diagnostic technologies. Further, this book features the wo...
Engineers at War (Hardcover)
NOTE: NO FURTHER DISCOUNT FOR THIS PRINTED PRODUCT- OVERSTOCK SALE -- Significantly reduced list price Engineers at War describes the role of military engineers, especially the U.S. Army Corps of Engineers, in the Vietnam War. It is a story of the engineers' battle against an elusive and determined enemy in one of the harshest underdeveloped regions of the world. Despite these challenges, engineer soldiers successfully carried out their combat and construction missions. The building effort in South Vietnam allowed the United States to deploy and operate a modern 500,000-man force in a far-off region. Although the engineers faced huge construction tasks, they were always ready to support the ...
We Gotta Get Out of This Place
“The diversity of voices and songs reminds us that the home front and the battlefront are always connected and that music and war are deeply intertwined.” —Heather Marie Stur, author of 21 Days to Baghdad For a Kentucky rifleman who spent his tour trudging through Vietnam’s Central Highlands, it was Nancy Sinatra’s “These Boots Are Made for Walkin’.” For a black marine distraught over the assassination of Martin Luther King Jr., it was Aretha Franklin’s “Chain of Fools.” And for countless other Vietnam vets, it was “I Feel Like I’m Fixin’ to Die” or the song that gives this book its title. In We Gotta Get Out of This Place, Doug Bradley and Craig Werner place po...
