Welcome to our book review site go-pdf.online!
You may have to Search all our reviewed books and magazines, click the sign up button below to create a free account.
Fever Supports CD8+ Effector T Cell Responses by Promoting Mitochondrial Translation
Abstract: Fever can provide a survival advantage during infection. Metabolic processes are sensitive to environmental conditions, but the effect of fever on T cell metabolism is not well characterized. We show that in activated CD8+ T cells, exposure to febrile temperature (39 °C) augmented metabolic activity and T cell effector functions, despite having a limited effect on proliferation or activation marker expression. Transcriptional profiling revealed an up-regulation of mitochondrial pathways, which was consistent with increased mass and metabolism observed in T cells exposed to 39 °C. Through in vitro and in vivo models, we determined that mitochondrial translation is integral to the enhanced metabolic activity and function of CD8+ T cells exposed to febrile temperature. Transiently exposing donor lymphocytes to 39 °C prior to infusion in a myeloid leukemia mouse model conferred enhanced therapeutic efficacy, raising the possibility that exposure of T cells to febrile temperatures could have clinical potential
Polyamines and EIF5A Hyusination Modulate Mitochondrial Respiration and Macrophage Activation
Abstract: How cells adapt metabolism to meet demands is an active area of interest across biology. Among a broad range of functions, the polyamine spermidine is needed to hypusinate the translation factor eukaryotic initiation factor 5A (eIF5A). We show here that hypusinated eIF5A (eIF5AH) promotes the efficient expression of a subset of mitochondrial proteins involved in the TCA cycle and oxidative phosphorylation (OXPHOS). Several of these proteins have mitochondrial targeting sequences (MTSs) that in part confer an increased dependency on eIF5AH. In macrophages, metabolic switching between OXPHOS and glycolysis supports divergent functional fates stimulated by activation signals. In these cells, hypusination of eIF5A appears to be dynamically regulated after activation. Using in vivo and in vitro models, we show that acute inhibition of this pathway blunts OXPHOS-dependent alternative activation, while leaving aerobic glycolysis-dependent classical activation intact. These results might have implications for therapeutically controlling macrophage activation by targeting the polyamine-eIF5A-hypusine axis
My Poetry Is Me
My Poetry is Me is more than a book of poems. It's a journey through joy and sorrow, loss and new beginnings. Join author Karen Ann Gill on this voyage as she learns to cope with the loss of her stepmother in Going Home and Damn that Killer. Dream with her about her daughter's wedding day in Remembering Yesterday. And think about what you will leave behind if today is your last day, as you read Who's Gonna Take Over. This book, and the words within, is what Karen will leave behind, so that when that day comes, people will know that she lived. From the earliest age the sounds of words drew her, and when old enough to follow them on paper she fell in love. Over the years I have had the pleasure of watching this love affair. Now you can too. Brook Johnson, the author's father Karen Ann Gill lives in Mansfield, Missouri with her husband and two children. She works in a small local restaurant. My Poetry is Me is just the beginning of her journey...there is much more to come. Publisher's Website: http: //www.strategicpublishinggroup.com/title/MyPoetryIsMe.htm
