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Age Related Macular Degeneration
Age-related Macular Degeneration (AMD) is the leading cause of vision loss and blindness in the developed countries. In the past decade, great progress has been made in understanding the pathobiology and genetics of this blinding disease, as well as in finding new therapies for its treatment. These include the discovery of several genes that are associated with the risk of AMD, new anti-VEGF treatments for wet AMD and new imaging techniques to diagnose and monitor the AMD. All chapters in this book were contributed by outstanding research scientists and clinicians in the area of AMD. I hope this timely book will provide the basic scientists and clinicians with an opportunity to learn about the recent advances in the field of AMD.
Optical Coherence Tomography in Neurologic Diseases
The first comprehensive review of the use of optical coherence tomography in neurological diseases for neurologists, neuro-ophthalmologists, and neuroradiologists.
Metal Nanocomposites in Nanotherapeutics for Oxidative Stress-Induced Metabolic Disorders
This book highlights the role and mechanism of different metal nanocomposites toward oxidative stress-induced metabolic disorders including metabolic pathways affected by oxidative stress and related pathophysiology. The book includes an illustrative discussion about the methods of synthesis, characterization, and biomedical applications of metal nanocomposites. It focuses on the therapeutic approaches for metabolic disorders due to oxidative stress by nano delivery systems. Moreover, the book includes chapters on nanotherapeutic approaches toward different diseases, including diabetes mellitus, obesity, cardiovascular disorders, cancers, and neurodegenerative diseases such as Alzheimer's di...
Principles and Practice of Clinical Trials
This is a comprehensive major reference work for our SpringerReference program covering clinical trials. Although the core of the Work will focus on the design, analysis, and interpretation of scientific data from clinical trials, a broad spectrum of clinical trial application areas will be covered in detail. This is an important time to develop such a Work, as drug safety and efficacy emphasizes the Clinical Trials process. Because of an immense and growing international disease burden, pharmaceutical and biotechnology companies continue to develop new drugs. Clinical trials have also become extremely globalized in the past 15 years, with over 225,000 international trials ongoing at this po...
Cure Models
Cure Models: Methods, Applications and Implementation is the first book in the last 25 years that provides a comprehensive and systematic introduction to the basics of modern cure models, including estimation, inference, and software. This book is useful for statistical researchers and graduate students, and practitioners in other disciplines to have a thorough review of modern cure model methodology and to seek appropriate cure models in applications. The prerequisites of this book include some basic knowledge of statistical modeling, survival models, and R and SAS for data analysis. The book features real-world examples from clinical trials and population-based studies and a detailed intro...
AMSTAT News
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Refractive Errors: Public Health Challenges and Interventions
This Research Topic is Volume 2 in the Research Topic series 'Myopia: Public Health challenges and interventions'. Uncorrected refractive errors are a significant cause of impaired vision and blindness in most world populations. During early childhood, uncorrected refractive errors may affect visual development and result in amblyopia. The largest burden of refractive error is myopia which significantly increases the risk of blinding conditions such as myopic macular degeneration, glaucoma, and cataract. High myopia poses greater risks than mild or moderate myopia. Epidemiological research and advocacy have positioned uncorrected refractive errors on the global health agenda as a major public health issue. However, more research is needed to determine the full extent of the threat posed by refractive errors, to establish effective interventions and to consolidate prevention methods.
