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The Amphipathic Helix
The Amphipathic Helix is a comprehensive volume discussing amphipathic helices in systems as diverse as serum lipoproteins, lung surfactant, cytotoxic peptides, ion channels, mitochondrial targeting, peptide hormones, G proteins, T-cell recognition, DNA binding proteins, and antifreeze proteins. The book also includes general introductory material that defines amphipathic helices, discusses methods to identify amphipathic helical segments from the amino acid sequence of a protein, illustrates how amphipathic helices can be used in the de novo design of peptide and protein structures, and describes how these helices stabilize protein structures. There is also a section on techniques to determine helix orientation in a membrane environment using polarized attenuated total reflection infrared spectroscopy or solid state NMR spectroscopy. Recent developments on all these topics have been discussed by leading experts in this reference for researchers and students in biochemistry, biophysics, and pharmacology.
The Biology of mRNA: Structure and Function
The book provides an overview on the different aspects of gene regulation from an mRNA centric viewpoint, including how mRNA is assembled and self-assembles in a complex consisting of RNA and proteins, and how its ability to be translated at the right time and space depends on many processes acting on the mRNAs, leading to a properly folded complex. This book shows how new technologies have led to a better understanding of these processes and their connected diseases.The book is written for scientists in fundamental and applied biomedical research working on different aspects of gene regulation. It is also targeted to an audience that is not implicated in these fields directly, but wants to gain a better understanding of mRNA biology.
The Digging Stick
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Food Around the World
Authentic, easy-to-follow recipes, questions, projects, and class investigations accompany each region investigated.
RNA Metabolism in Neurodegenerative Diseases
It has become evident over the last years that abnormalities in RNA processing play a fundamental part in the pathogenesis of neurodegenerative diseases. Cellular viability depends on proper regulation of RNA metabolism and subsequent protein synthesis, which requires the interplay of many processes including transcription, pre--‐mRNA splicing, mRNA editing as well as mRNA stability, transport and translation. Dysfunction in any of these processes, often caused by mutations in the coding and non--‐ coding RNAs, can be very destructive to the cellular environment and consequently impair neural viability. The result of this RNA toxicity can lead to a toxic gain of function or a loss of fun...
Cap-Analysis Gene Expression (CAGE)
This book is a guide for users of new technologies, as it includes accurately proven protocols, allowing readers to prepare their samples for experiments. Although examples mainly concern mammalians, the discussion expands to other groups of eukaryotes, where these approaches are complementing genome sequencing.
Sleep Better! a Guide to Improving Sleep for Children with Special Needs
This fully updated edition includes help for parents who usually struggle with nighttime problems. Without preaching or proposing a "one right way" to solve problems, psychologist and father Mark Durand helps families tackle sleep issues with optimism and proven strategies drawn from clinical and personal experience.
Autoimmune Neurology
Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders ...
The Upper Paleolithic of the Central Russian Plain
The Upper Paleolithic of the Central Russian Plain examines the hunter-gatherer adaptations on the Upper Paleolithic central Russian Plain. The book offers both a culture history for the area and an explanation for the changes in human adaptation. It presents what has been found at 29 major Upper Paleolithic sites occupied over a period of some 14,000 years. The book presents details of the archaeological inventories and assemblages found at the 29 sites, together with the geography and geology of the study area. It then uses environmental data to model environmental conditions and resource distribution during the various periods of human occupation, as well as to predict optimal strategies for exploiting available resources. Subsequent chapters present the relative and chronometric dating schemes. The book also elucidates the man-land relationships, ensuing subsistence strategies, settlement types present in the archaeological record, settlement systems, and sociopolitical behavior. The text will be significant to archaeologists, paleoecologists, and anthropologists interested in hunter-gatherers and late Pleistocene adaptations.
