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Brain aminergic pathways are organized in parallel and interacting systems, which support a range of functions, from homoeostatic regulations to cognitive, and motivational processes. Despite overlapping functional influences, dopamine, serotonin, noradrenaline and histamine systems provide different contributions to these processes. The histaminergic system, long ignored as a major regulator of the sleep-wake cycle, has now been fully acknowledged also as a major coordinator of attention, learning and memory, decision making. Although histaminergic neurons project widely to the whole brain, they are functionally heterogeneous, a feature which may provide the substrate for differential regul...
Reveals an Emerging Avenue of Potential Treatments for a Host of Challenging Diseases and Disorders The H3 receptor is known to play a major role in a range of CNS disorders, including those affecting cognitive functions such as ADHD and Alzheimer’s disease, as well as sleep disorders, obesity, epilepsy, schizophrenia, depression, and neurodegeneration. In light of dramatic advances in research at the molecular level, supported by impressive clinical studies, optimism remains high that an H3 receptor-related drug could hit the market soon. The Third Histamine Receptor: Selective Ligands as Potential Therapeutic Agents in CNS Disorders provides a thorough grounding in advances made over the...
With the rapid development of machinery, materials science and energy engineering technology in China, new theories and application results constantly appear. Higher and newer requirements in these fields are sought by business enterprises and members of the engineering profession. This conference was held to further promote the exchange and cooperation among local researchers, to upgrade the academic standards and international influence on the study of these fields in China, and to play a positive role in bridging the gap with the international research community. This volume consists of 106 peer-reviewed articles by local and foreign eminent scholars which cover the frontiers and hot topics in machinery and process equipment, materials science, energy engineering and mechatronics. Contents:Machinery and Process EquipmentMaterials ScienceEnergy EngineeringMechatronics Engineering Readership: Researchers and professional. Key Features:The proceedings collected together R&D results recently funded and undertaken by researchers from China, and other countriesKeywords:Machinery and Process Equipment;Materials Science;Energy Engineering;Mechatronics Mechanics
Infants and children spend one- to two-thirds of their life asleep. Despite this, very little attention has been paid to understanding both normal sleep and sleep-related abnormalities during child development. There are profound changes in sleep and circadian rhythm during growth and maturation. Sleep is particularly important in children, due to
Very little is known about the issue of wildlife conservation within China. Even China specialists get a meager ration of stories about pandas giving birth in zoos, or poachers in some remote setting being apprehended. But what does the future hold for China's wildlife? In this thoughtful work the leading U.S. expert on wildlife projects in Western China presents a multi-faceted assessment of the topic. Richard B. Harris draws on twenty years of experience working in China, and incorporates perspectives ranging from biology through Chinese history and tradition, to interpret wildlife conservation issues in a cultural context. In non-technical language, Harris shows that, particularly in its ...
The International Conference on Intelligent Computing (ICIC) was formed to provide an annual forum dedicated to the emerging and challenging topics in artificial intel- gence, machine learning, pattern recognition, image processing, bioinformatics, and computational biology. It aims to bring together researchers and practitioners from both academia and industry to share ideas, problems, and solutions related to the m- tifaceted aspects of intelligent computing. ICIC 2010, held in Changsha, China, August 18-21, 2010, constituted the 6th - ternational Conference on Intelligent Computing. It built upon the success of ICIC 2009, ICIC 2008, ICIC 2007, ICIC 2006, and ICIC 2005, that were held in U...
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