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Precision Approaches to Heterogeneity in Asthma
Asthma is a common chronic respiratory disease that causes substantial morbidity and has been challenging to treat due to its heterogeneous onset, environmental triggers, severity, and treatment response. To update the field on the rapid advances in this field, Precision Approaches to Heterogeneity in Asthma follows its highly successful predecessor, Heterogeneity in Asthma. In this new volume, noted authorities Allan R Brasier and Nizar N Jarjour and a cadre of leaders in the field incorporate new work advancing our understanding of phenotypes (endotypes) of disease, regional variations in ventilation, systems approach to analyzing the findings from studies of inducible phenotypes, and emerging results of biomarker-informed clinical trials. This work will facilitate our current understanding of the spectrum of disease etiology, prognosis, and the likelihood of responding to the range of available therapeutic interventions.
Artificial Intelligence Technologies for Computational Biology
This text emphasizes the importance of artificial intelligence techniques in the field of biological computation. It also discusses fundamental principles that can be applied beyond bio-inspired computing. It comprehensively covers important topics including data integration, data mining, machine learning, genetic algorithms, evolutionary computation, evolved neural networks, nature-inspired algorithms, and protein structure alignment. The text covers the application of evolutionary computations for fractal visualization of sequence data, artificial intelligence, and automatic image interpretation in modern biological systems. The text is primarily written for graduate students and academic ...
Asthma, An Issue of Clinics in Chest Medicine
This issue of Clinics in Chest Medicine, edited by Dr. Serpil Erzurum and Dr. Sumita Khatri, is devoted to several key areas of interest related to understanding Asthma and its treatments. Topics covered in this issue include: Epidemiology of the Asthma Epidemic in the 21st Century; Classification of Asthma; Genetics and Epigenetics of Asthma; Pro-Inflammatory Pathways in the Pathogenesis of Asthma; Dysfunction of Bronchomotor Tone Pathways in Asthmatic Airway Smooth Muscle; Systematic Approach to Asthma of Varying Severity; Comorbidities and Non-allergic Triggers in Asthma Exacerbations and Severity; Microbiome in Mechanisms of Asthma; Diet and Metabolism in the Evolution of Asthma and Obesity; The Exposome of Asthma; Life Cycle of Childhood Asthma; Asthma over the Adult Lifecourse, considering Gender and Hormonal Influences; Asthma and Corticosteroid Responses in Childhood and Adult Asthma; Immunomodulators and Biologics; Bronchial Thermoplasty; Population Health Models for Asthma; and The Future of Asthma Care: Personalized Asthma Treatment.
Sex-Based Differences in Lung Physiology
This book provides an overview of the latest experimental work on sex-based differences in lung function and inflammation. Readers will learn how these differences relate to individual predispositions for the development of lung disease in men and women, and in different stages of their reproductive lives. Further, the book focuses on diseases that predominantly affect women or men, with an emphasis on the physiological mechanisms underlying their pathobiology. In turn, these findings are complemented by chapters on recent studies, which investigate how circulating sex hormone levels impact the lung’s innate immune response to environmental agents and air pollution. The pathogeneses of asthma and viral respiratory infection are also major focus areas. As an outlook, the book also discusses current and future research directions aimed at developing sex-specific therapies for lung disease. To examine these anatomical and physiological differences in the male and female respiratory systems, the authors employ a broad range of methods from molecular and clinical biology. Accordingly, the book will be a fascinating read for physiologists and clinicians alike.
Sex-Based Differences in Lung Physiology
This book provides an overview of the latest experimental work on sex-based differences in lung function and inflammation. Readers will learn how these differences relate to individual predispositions for the development of lung disease in men and women, and in different stages of their reproductive lives. Further, the book focuses on diseases that predominantly affect women or men, with an emphasis on the physiological mechanisms underlying their pathobiology. In turn, these findings are complemented by chapters on recent studies, which investigate how circulating sex hormone levels impact the lung’s innate immune response to environmental agents and air pollution. The pathogeneses of asthma and viral respiratory infection are also major focus areas. As an outlook, the book also discusses current and future research directions aimed at developing sex-specific therapies for lung disease. To examine these anatomical and physiological differences in the male and female respiratory systems, the authors employ a broad range of methods from molecular and clinical biology. Accordingly, the book will be a fascinating read for physiologists and clinicians alike.
Sam the Cooking Guy: Recipes with Intentional Leftovers
20 master recipes, more than 100 dishes—weeknight cooking has never been so exciting or so easy! Say goodbye to fourth-night-in-a-row meat loaf and identical containers of tragically “meal-prepped” chicken thighs. YouTube cooking sensation and restauranteur Sam the Cooking Guy is here to save us from mediocre leftovers. With 20 bulk-cooking master dishes, each featuring a main protein, with corresponding follow-up meals that all benefit from the work you’ve already done, Sam ensures that you’ll never be bored in the kitchen again! Sam’s recipes are simple and quick, but never tired. Your Mexican Meat Loaf from Sunday can shapeshift into Tuesday night’s Tacos or Thursday’s Sloppy Joes. Monday’s Roast Chicken becomes Wednesday’s Thai Chicken Curry or Friday’s Baked Taquitos. “Aw man, Beer-Braised Short Ribs again?” “Nah: Short Rib Egg Rolls!” Sam’s genuine and engaging personality, along with vibrant color photography, makes this book a lifesaver for busy folks who are looking for dinners that they can finally be excited about.
Retinal Degenerative Diseases XIX
This book contains the proceedings of the XVIII International Symposium on Retinal Degeneration (RD2018). A majority of those who spoke and presented posters at the meeting contributed to this volume. The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70. The RD Symposium focused on the exciting new developments aimed at understanding these diseases and providing therapies for them. Since most major scientists in the field of retinal degenerations attend the biennial RD Symposia, they are known by most as the “best” a...
Hodge Theory (MN-49)
This book provides a comprehensive and up-to-date introduction to Hodge theory—one of the central and most vibrant areas of contemporary mathematics—from leading specialists on the subject. The topics range from the basic topology of algebraic varieties to the study of variations of mixed Hodge structure and the Hodge theory of maps. Of particular interest is the study of algebraic cycles, including the Hodge and Bloch-Beilinson Conjectures. Based on lectures delivered at the 2010 Summer School on Hodge Theory at the ICTP in Trieste, Italy, the book is intended for a broad group of students and researchers. The exposition is as accessible as possible and doesn't require a deep background...
